4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

Base Information

Chemical Name:4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid
CAS No.:1370748-99-4
Molecular Formula:C₂₄H₂₃N₅O₆
Molecular Weight:477.477
Hs Code.:

Synonyms:4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

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Chemical Property of 4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

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Technology Process of 4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

There total 6 articles about 4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1312592-14-5
C₁₃H₁₃NO₃

: 1370749-08-8
4-azido-4-(benzo[d]oxazol-2-yl)butanoic acid

: 1370748-99-4
4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

Guidance literature:: With triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201496g

Reference yield:

: C₁₁H₁₂N₂O₃

: 1370748-99-4
4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

2: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm201496g

Reference yield:

: 1370749-26-0
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

: 1370748-99-4
4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g