tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate
CAS No.:1370749-26-0
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

Synonyms:tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

Suppliers and Price of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

There total 1 articles about tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 13726-84-6,104719-63-3
5-(tert-butoxy)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

: 95-55-6
2-amino-phenol

: 1370749-26-0
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201496g

Reference yield:

: 1370749-26-0
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

: C₂₄H₂₄N₆O₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5.1: N-methylcyclohexylamine; ammonia; isobutyl chloroformate / tetrahydrofuran / 1.75 h / -30 - 20 °C

With N-methylcyclohexylamine; hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; ammonia; N-ethyl-N,N-diisopropylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g

Reference yield:

: 1370749-26-0
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate

: 1370748-99-4
4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g