ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

Base Information

Chemical Name:ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate
CAS No.:1431790-48-5
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:

Synonyms:ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

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Chemical Property of ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

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Technology Process of ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

There total 3 articles about ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 33654-16-9,33681-56-0,50901-80-9
erythro-(4S,5R)-5-methyl-4-phenylpyrrolidin-2-one

: 105-36-2
ethyl bromoacetate

: 1431790-48-5
ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

Guidance literature:: erythro-(4S,5R)-5-methyl-4-phenylpyrrolidin-2-one; With sodium hydride; In toluene; at 80 - 90 ℃; for 0.5h;

ethyl bromoacetate; In toluene; at 110 - 120 ℃; for 6h;
DOI:10.1016/j.bmc.2013.03.016

Reference yield:

: methyl erythro-(3S,4R)-4-nitro-3-phenylpentanoate

: 1431790-48-5
ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ni Raney / water; ethanol / 18 h / 50 °C / 38002.6 Torr

2.1: sodium hydride / toluene / 0.5 h / 80 - 90 °C

2.2: 6 h / 110 - 120 °C

With sodium hydride; In ethanol; water; toluene;
DOI:10.1016/j.bmc.2013.03.016

Reference yield:

: (3S)-4-nitro-3-phenylpentanoic acid

: 1431790-48-5
ethyl erythro-(4S,5R)-2-(5-methyl-4-phenylpyrrolidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / methanol / 6 h / Reflux

2.1: Ni Raney / water; ethanol / 18 h / 50 °C / 38002.6 Torr

3.1: sodium hydride / toluene / 0.5 h / 80 - 90 °C

3.2: 6 h / 110 - 120 °C

With thionyl chloride; sodium hydride; In methanol; ethanol; water; toluene;
DOI:10.1016/j.bmc.2013.03.016