(3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol

Base Information

• Chemical Name: (3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol
• CAS No.: 1172135-82-8
• Molecular Formula: C₃₈H₆₂O₄Si
• Molecular Weight: 610.993

Synonyms:(3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol

Chemical Property of (3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol

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Technology Process of (3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol

There total 1 articles about (3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(4S,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-one (1172135-80-6) → (3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol (1172135-82-8)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃; for 24h;

DOI:10.1055/s-0028-1088011

Reference yield: 60.0%

(3R,4R,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-ol (1172135-82-8) + t-butyldimethylsiyl triflate (69739-34-0) → (5R,6S,7S,11S,12S,13R)-5,13-diethyl-2,2,3,3,6,12,15,15,16,16-decamethyl-9-methylene-7,11-bis[(1S)-1-phenylethoxy]-4,14-dioxa-3,15-disilaheptadecane (1172135-84-0)

Guidance literature:

With triethylamine; In dichloromethane; at -20 ℃; for 2h;

DOI:10.1055/s-0028-1088011

upstream raw materials:

(4S,5S)-7-{(2S,3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methyl-2-[(1S)-1-phenylethoxy]hexyl}-4-methyl-5-[(1S)-1-phenylethoxy]oct-7-en-3-one

Downstream raw materials:

(5R,6S,7S,11S,12S,13R)-5,13-diethyl-2,2,3,3,6,12,15,15,16,16-decamethyl-9-methylene-7,11-bis[(1S)-1-phenylethoxy]-4,14-dioxa-3,15-disilaheptadecane

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