4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

Base Information

Chemical Name:4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester
CAS No.:796072-26-9
Molecular Formula:C₂₂H₂₆BrNO₅
Molecular Weight:464.356
Hs Code.:

Synonyms:4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

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Chemical Property of 4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

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Technology Process of 4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

There total 1 articles about 4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 29558-77-8
4-bromo-4'-hydroxybiphenyl

: 76969-87-4
methyl (2S)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate

: 796072-26-9
4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

Guidance literature:: 4-bromo-4'-hydroxybiphenyl; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.166667h;

methyl (2S)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate; In DMF (N,N-dimethyl-formamide); for 16h;

Reference yield:

: 796072-26-9
4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

: 100124-06-9
4-dibenzofurylboronic acid

: 2-tert-butoxycarbonylamino-4-(4'-dibenzofuran-4-yl-biphenyl-4-yloxy)butyric acid methyl ester

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 2h; Heating / reflux;

Reference yield:

: 796072-26-9
4-(4'-bromobiphen-4-yloxy)-2-tert-butoxycarbonylaminobutyric acid methyl ester

: 2-tert-butoxycarbonylamino-4-(4'-dibenzofuran-4-yl-biphenyl-4-yloxy)butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 h / Heating / reflux

2: potassium hydroxide; water / tetrahydrofuran; methanol / 1 h / 0 °C

With potassium hydroxide; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; toluene; 1: Suzuki Coupling;