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76969-87-4

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76969-87-4 Usage

General Description

Methyl (S)-2-(Boc-aMino)-4-broMobutyrate is a chemical compound with the molecular formula C13H21NO5. It is a derivative of Boc-protected amino acids, commonly used in organic synthesis and peptide chemistry. The compound has a methyl ester group, a Boc-protected amino group, and a bromo-substituted butyrate chain. It is used as a building block in the synthesis of complex organic compounds, including peptides and pharmaceutical agents. Methyl (S)-2-(Boc-aMino)-4-broMobutyrate is a versatile chemical reagent with various applications in the field of medicinal chemistry and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 76969-87-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,9,6 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76969-87:
(7*7)+(6*6)+(5*9)+(4*6)+(3*9)+(2*8)+(1*7)=204
204 % 10 = 4
So 76969-87-4 is a valid CAS Registry Number.

76969-87-4Downstream Products

76969-87-4Relevant articles and documents

Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy

Mann, Guy,Satish, Gandhesiri,Sulkshane, Prasad,Mandal, Shaswati,Glickman, Michael H.,Brik, Ashraf

, p. 9438 - 9441 (2021/09/22)

Protein post-translational modifications are involved in essentially all aspects of cellular signaling. Their dynamic nature and the difficulties in installing them using enzymatic approaches limits their direct study in human cells. Reported herein is the first synthesis, delivery and cellular study of a stable phosphoubiquitin probe. Our results compare Parkin's substrate preference during mitophagyviadirect visualization of a phosphorylated ubiquitin probe in the cellular environment.

Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

Donoghue, Craig,Cubillos-Rojas, Monica,Gutierrez-Prat, Nuria,Sanchez-Zarzalejo, Carolina,Verdaguer, Xavier,Riera, Antoni,Nebreda, Angel R.

supporting information, (2020/07/06)

We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked to thalidomide analogues to recruit the Cereblon E3 ubiquitin ligase complex. Compound synthesis was facilitated by the use of a copper catalyzed “click” reaction. We show that optimization of the linker length and composition is crucial for the degradation-inducing activity of these PROTACs. We provide evidence that these chemical compounds can induce degradation of p38α and p38β but no other related kinases at nanomolar concentrations in several mammalian cell lines. Accordingly, the PROTACs inhibit stress and cytokine-induced p38α signaling. Our compounds contribute to understanding the development of PROTACs, and provide a useful tool to investigate functions of the p38 MAPK pathway and its involvement in diseases.

ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

-

, (2016/08/10)

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

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