(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

Base Information

Chemical Name:(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester
CAS No.:173423-74-0
Molecular Formula:C₁₆H₂₃FO₃Si
Molecular Weight:310.441
Hs Code.:

Synonyms:(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

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Chemical Property of (E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

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Technology Process of (E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

There total 3 articles about (E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 173423-74-0
(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / 4-(N,N-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: aq. NaOH / methanol / 5 h / Ambient temperature

3: 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 14 h / Ambient temperature

With dmap; sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e

Reference yield:

: 94844-37-8
ethyl (2E)-4-{[tert-butyl(dimethyl)silyl]oxy}but-2-enoate

: 173423-74-0
(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 5 h / Ambient temperature

2: 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 14 h / Ambient temperature

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e

Reference yield:

: 371-41-5
4-Fluorophenol

: (E)-4-((tert-butyldimethylsilyl)oxy)but-2-enoic acid

: 173423-74-0
(E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; for 14h; Yield given; Ambient temperature;
DOI:10.1021/jo951653e