Technology Process of 3-(2,6-Dichloro-4-isopropoxy-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one Hydrochloride
There total 12 articles about 3-(2,6-Dichloro-4-isopropoxy-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one Hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 17 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -67 °C
2.2: 3 h / -78 °C
3.1: water; toluene-4-sulfonic acid / acetone / 24 h / 20 °C
3.2: 1 h / 45 °C
4.1: triethylamine / 140 °C
5.1: hydrazine / ethanol / 72 h / 20 °C
6.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C
6.2: 0.25 h / 0 °C
6.3: pH 7
7.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; N,N-dimethyl-formamide / 41 h / 60 °C
8.1: hydrogenchloride / diethyl ether; dichloromethane
With
hydrogenchloride; tributylphosphine; water; boron tribromide; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; triethylamine; hydrazine; 1,1'-azodicarbonyl-dipiperidine; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
7.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2.1: sodium tetrahydroborate / ethanol / 2 h / 0 - 7 °C
3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -67 °C
4.2: 3 h / -78 °C
5.1: water; toluene-4-sulfonic acid / acetone / 24 h / 20 °C
5.2: 1 h / 45 °C
6.1: triethylamine / 140 °C
7.1: hydrazine / ethanol / 72 h / 20 °C
8.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C
8.2: 0.25 h / 0 °C
8.3: pH 7
9.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; N,N-dimethyl-formamide / 41 h / 60 °C
10.1: hydrogenchloride / diethyl ether; dichloromethane
With
hydrogenchloride; sodium tetrahydroborate; tributylphosphine; water; boron tribromide; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; hydrazine; 1,1'-azodicarbonyl-dipiperidine; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
9.1: Mitsunobu reaction;
