(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Base Information

Chemical Name:(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide
CAS No.:172269-40-8
Molecular Formula:C₂₃H₄₁NO₅Si
Molecular Weight:439.668
Hs Code.:

Synonyms:(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

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Chemical Property of (2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

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Technology Process of (2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

There total 5 articles about (2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172269-36-2
(S)-4-benzyl-3-{(2S,3R,4R)-3-hydroxy-5-[(4methoxybenzyl)oxy]-2,4-dimethylpentanoyl}oxazolidin-2-one

: 172269-40-8
(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / AlMe₃ / tetrahydrofuran

2: 100 percent / 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; trimethylaluminum; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00153a030

Reference yield:

: 160238-46-0
(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal

: 172269-40-8
(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-Bu₂BOTf, Et₃N / CH₂Cl₂

2: 89 percent / AlMe₃ / tetrahydrofuran

3: 100 percent / 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00153a030

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 172269-40-8
(2S,2R,4R)-3-[(tert-butyldimethylsilyl)oxy]-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Guidance literature:: Multi-step reaction with 6 steps

1: PPTS / CH₂Cl₂; cyclohexane

2: LiAlH₄ / tetrahydrofuran

3: (COCl)2, DMSO

4: n-Bu₂BOTf, Et₃N / CH₂Cl₂

5: 89 percent / AlMe₃ / tetrahydrofuran

6: 100 percent / 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/ja00153a030