trans-N-cyclohexyl-2-methylcyclohexylamine

Base Information

• Chemical Name: trans-N-cyclohexyl-2-methylcyclohexylamine
• CAS No.: 59083-13-5
• Molecular Formula: C₁₃H₂₅N
• Molecular Weight: 195.348
• Mol file: 59083-13-5.mol

Synonyms:trans-N-cyclohexyl-2-methylcyclohexylamine

Chemical Property of trans-N-cyclohexyl-2-methylcyclohexylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trans-N-cyclohexyl-2-methylcyclohexylamine

There total 4 articles about trans-N-cyclohexyl-2-methylcyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenyl-2-methylcyclohexylamine (189238-63-9) → cis-N-cyclohexyl-2-methylcyclohexylamine (86834-27-7) + trans-N-cyclohexyl-2-methylcyclohexylamine (59083-13-5)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In methanol; acetic acid; for 10h; under 2172.02 Torr; Yield given. Yields of byproduct given;

DOI:10.1021/jo00168a009

Reference yield:

cyclohexyl(2-methylcyclohexylidene)amine (20007-02-7) → cis-N-cyclohexyl-2-methylcyclohexylamine (86834-27-7) + trans-N-cyclohexyl-2-methylcyclohexylamine (59083-13-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at 56 ℃; for 24h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00168a009

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → trans-N-cyclohexyl-2-methylcyclohexylamine (59083-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / p-toluenesulfonic acid / benzene / Heating

2: NaAlH₂(OCH₂CH₂OCH₃)2 / tetrahydrofuran / 24 h / 56 °C

With toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; benzene;

DOI:10.1021/jo00168a009

upstream raw materials:

cyclohexyl(2-methylcyclohexylidene)amine

N-phenyl-2-methylcyclohexylamine

cyclohexylamine

2-Methylcyclohexanone