6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene

Base Information

• Chemical Name: 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene
• CAS No.: 222529-60-4
• Molecular Formula: C₃₈H₃₀N₄O₅
• Molecular Weight: 622.68
• Mol file: 222529-60-4.mol

Synonyms:6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene

Chemical Property of 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene

There total 7 articles about 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(2-carboxyphenyl)-(pyridin-3-yl)-ketone (137382-32-2) + 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene (186461-60-9) → 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene (222529-60-4)

Guidance literature:

In ethylene glycol; at 120 ℃; for 4h;

DOI:10.1021/jm980314l

Reference yield:

2-chloropyridine-4-carbaldehyde (101066-61-9) → 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene (222529-60-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: AcOH / xylene / 2 h / Heating

3: BF₃*Et₂O / acetonitrile / 3 h / Heating

4: 60 percent / Red-Al / tetrahydrofuran; toluene / 1 h / Ambient temperature

5: 88 percent / NH₂NH₂*H₂O / 2 h / Heating

6: 55 percent / ethane-1,2-diol / 4 h / 120 °C

With n-butyllithium; boron trifluoride diethyl etherate; hydrazine hydrate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethylene glycol; toluene; acetonitrile; xylene;

DOI:10.1021/jm980314l

Reference yield:

6-bromo-3-benzyloxy-4-methoxybenzaldehyde dimethyl acetal (155044-04-5) → 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene (222529-60-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: AcOH / xylene / 2 h / Heating

3: BF₃*Et₂O / acetonitrile / 3 h / Heating

4: 60 percent / Red-Al / tetrahydrofuran; toluene / 1 h / Ambient temperature

5: 88 percent / NH₂NH₂*H₂O / 2 h / Heating

6: 55 percent / ethane-1,2-diol / 4 h / 120 °C

With n-butyllithium; boron trifluoride diethyl etherate; hydrazine hydrate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethylene glycol; toluene; acetonitrile; xylene;

DOI:10.1021/jm980314l

upstream raw materials:

(2-carboxyphenyl)-(pyridin-3-yl)-ketone

6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene

2-chloropyridine-4-carbaldehyde

6-bromo-3-benzyloxy-4-methoxybenzaldehyde dimethyl acetal