101066-61-9

Basic information

• Product Name: 2-Chloroisonicotinaldehyde
• Synonyms: 2-CHLOROISONICOTINALDEHYDE;2-CHLOROPYRIDINE-4-CARBOXALDEHYDE;2-CHLOROPYRIDINE-3-CARBOXALDEHYDE;2-CHLOROPYRIDINE-4-CARBALDEHYDE;2-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLORO-4-FORMYLPYRIDINE;CHLORO-2-FORMYL-3-PYRIDINE;BUTTPARK 154\50-03
• CAS NO: 101066-61-9
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Product Categories: PYRIDINE;ALDEHYDE;pharmacetical;Aldehydes;Pyridines;Building Blocks;C1 to C6;C5 to C6;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 101066-61-9.mol

Chemical Properties

• Melting Point: 50-54 °C(lit.)
• Boiling Point: 243.4 °C at 760 mmHg
• Flash Point: >230 °C
• Appearance: White to yellow solid
• Density: 1.332 g/cm³
• Vapor Pressure: 0.0321mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.23±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 7986625
• CAS DataBase Reference: 2-Chloroisonicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloroisonicotinaldehyde(101066-61-9)
• EPA Substance Registry System: 2-Chloroisonicotinaldehyde(101066-61-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36-43-36/37/38-20/21/22-42/43
• Safety Statements: 26-36/37-36/37/39-22-45-23
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 101066-61-9(Hazardous Substances Data)

Usage

Uses

Used in Chemoenzymic Synthesis:
2-Chloroisonicotinaldehyde is used as a reagent in the chemoenzymic synthesis of α-fluoro β-hydroxy carboxylic esters. Its presence in this process allows for the efficient and selective formation of these esters, which are important building blocks in the development of pharmaceuticals and agrochemicals.
Used in Combinatorial Synthesis:
In the field of combinatorial chemistry, 2-Chloroisonicotinaldehyde is utilized as a reagent for the synthesis of methylene sulfonamides and related compounds. These compounds are of interest as potential kinase inhibitors, which can be used in the development of targeted therapies for various diseases, including cancer and inflammatory disorders.
Used in Pharmaceutical Industry:
2-Chloroisonicotinaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it an essential component in the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloroisonicotinaldehyde is employed as a building block for the synthesis of novel agrochemicals. Its incorporation into these compounds can lead to the development of more effective and environmentally friendly pesticides and herbicides.
Overall, 2-Chloroisonicotinaldehyde is a valuable reagent with a wide range of applications across different industries, particularly in the development of pharmaceuticals and agrochemicals. Its unique chemical properties and versatility in synthesis processes make it an essential component in the creation of innovative and effective products.

InChI:InChI=1/C6H4ClNO/c7-6-3-5(4-9)1-2-8-6/h1-4H

Upstream product

• 58481-11-1 methyl 2-chloroisonicotinate 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 497-19-8 sodium carbonate 
• 584-08-7 potassium carbonate 
• 6313-54-8 2-chloroisonicotinic acid, 
• 79-37-8 oxalyl dichloride 
• 14906-59-3 4-cyanopyridine N-oxide 

Downstream Products

• 915799-01-8 4'-(2-chloropyridine)-2,2',6',2''-terpyridine 
• 656257-67-9 2-(4-ethanesulfonylphenyl)-pyridine-4-carboxaldehyde 
• 868735-44-8 tert-butyl 4-((2-chloropyridin-4-yl)(hydroxy)methyl)-3-fluorophenylcarbamate 
• 1570043-58-1 (2-chloropyridin-4-yl)(1-methyl-4-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-imidazol-2-yl)methanol 
• 1426389-03-8 4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile 
• 222529-60-4 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene 
• 222529-57-9 7-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-6-methoxynaphthalene 
• 186461-60-9 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene 
• 186462-14-6 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene 
• 222529-46-6 7-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-6-methoxynaphthalene 
• 186461-59-6 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene 
• 204577-56-0 7-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-6-methoxynaphthalene 
• 1027833-34-6 (4-benzyloxy-2-dimethoxymethyl-5-methoxy-phenyl)-(2-chloro-pyridin-4-yl)-methanol 
• 204577-55-9 (5-Benzyloxy-2-dimethoxymethyl-4-methoxy-phenyl)-(2-chloro-pyridin-4-yl)-methanol 

Relevant articles and documents

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

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Naphthalene derivatives, process for the preparation thereof, and intermediates therefor

Naphthalene derivatives of the formula [I]: STR1 wherein R1 and R2 are the same or different and are each H, protected or unprotected OH, one of R3 and R4 is protected or unprotected hydroxymethyl, and the other is H, lower alkyl, or protected or unprotected hydroxymethyl, R5 and R6 are the same or different and are each H, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl or protected or unprotected NH2, or both combine together with the adjacent N to form substituted or unsubstituted heterocyclic group, and pharmaceutically acceptable salts thereof, these compounds showing excellent bronchoconstriction inhibitory activity, and hence, being useful in the prophylaxis or treatment of asthma.

Substituted imidazole compounds

This invention relates to a novel group of imidazole compounds, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and pharmaceutical compositions for use in such therapy.

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Imidazole compounds and compositions

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