101066-61-9

Basic information

• Product Name: 2-Chloroisonicotinaldehyde
• Synonyms: 2-CHLOROISONICOTINALDEHYDE;2-CHLOROPYRIDINE-4-CARBOXALDEHYDE;2-CHLOROPYRIDINE-3-CARBOXALDEHYDE;2-CHLOROPYRIDINE-4-CARBALDEHYDE;2-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLORO-4-FORMYLPYRIDINE;CHLORO-2-FORMYL-3-PYRIDINE;BUTTPARK 154\50-03
• CAS NO: 101066-61-9
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Product Categories: PYRIDINE;ALDEHYDE;pharmacetical;Aldehydes;Pyridines;Building Blocks;C1 to C6;C5 to C6;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 101066-61-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 50-54 °C(lit.)
• Boiling Point: 243.4 °C at 760 mmHg
• Flash Point: >230 °C
• Appearance: White to yellow solid
• Density: 1.332 g/cm³
• Vapor Pressure: 0.0321mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.23±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 7986625
• CAS DataBase Reference: 2-Chloroisonicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloroisonicotinaldehyde(101066-61-9)
• EPA Substance Registry System: 2-Chloroisonicotinaldehyde(101066-61-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36-43-36/37/38-20/21/22-42/43
• Safety Statements: 26-36/37-36/37/39-22-45-23
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 101066-61-9(Hazardous Substances Data)

Usage

Chemical Properties

white to yellow solid

Uses

2-Chloropyridine-4-carboxaldehyde is a reagent used in the chemoenzymic synthesis of α-fluoro β-hydroxy carboxylic esters. It is also a reagent in the combinatorial synthesis of methylene sulfonamides and related compounds as potential kinase inhibitors.

InChI:InChI=1/C6H4ClNO/c7-6-3-5(4-9)1-2-8-6/h1-4H

Upstream product

• 58481-11-1 methyl 2-chloroisonicotinate 
• 6313-54-8 2-chloroisonicotinic acid, 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 497-19-8 sodium carbonate 
• 584-08-7 potassium carbonate 
• 79-37-8 oxalyl dichloride 
• 14906-59-3 4-cyanopyridine N-oxide 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Downstream Products

• 915799-01-8 4'-(2-chloropyridine)-2,2',6',2''-terpyridine 
• 1419221-63-8 tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 1214381-00-6 2-phenylisonicotinaldehyde 
• 4634-12-2 4-(hydroxymethyl)-2-phenylpyridine 
• 1426389-03-8 4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile 
• 1204296-03-6 2-chloro-4-(difluoromethyl)pyridine 
• 109919-29-1 2-chloro-4-[chloro(difluoro)methyl]pyridine 
• 1570043-58-1 (2-chloropyridin-4-yl)(1-methyl-4-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-imidazol-2-yl)methanol 

Relevant articles and documents

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formulas 1 and 2 wherein the variables have the meaning disclosed in the specification

Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

Substituted imidazole compounds

This invention relates to a novel group of imidazole compounds, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and pharmaceutical compositions for use in such therapy.