Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Name:Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester
CAS No.:117854-37-2
Molecular Formula:C₂₈H₃₉N₆O₇P
Molecular Weight:602.627
Hs Code.:

Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Synonyms:Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

There total 1 articles about Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 92611-10-4
bis(N,N-diisopropylamino)methoxyphosphine

: 63660-23-1
3'-O-benzoyl-N²-isobutyryl-2'-deoxyguanosine

: 117854-37-2
Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; at 30 ℃; for 1h;
DOI:10.1248/cpb.36.1386

Reference yield:

: 117854-37-2
Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: C₃₇H₄₅N₆O₉P

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole, I₂

2: 86 percent / NaOH / methanol; pyridine; H₂O / 0.17 h / 0 °C

With 1H-tetrazole; sodium hydroxide; iodine; In pyridine; methanol; water;
DOI:10.1248/cpb.36.1386

Reference yield:

: 117854-37-2
Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: C₄₄H₆₁N₇O₁₀P₂

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-tetrazole, I₂

2: 86 percent / NaOH / methanol; pyridine; H₂O / 0.17 h / 0 °C

3: 70 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

With 1H-tetrazole; sodium hydroxide; N,N-diisopropylamine tetrazolide; iodine; In pyridine; methanol; dichloromethane; water;
DOI:10.1248/cpb.36.1386