Chemical Property of Hexaconazole
Chemical Property:
- Vapor Pressure:1.99E-10mmHg at 25°C
- Melting Point:111 °C
- Refractive Index:1.597
- Boiling Point:490.3 °C at 760 mmHg
- PKA:12.26±0.29(Predicted)
- Flash Point:250.3 °C
- PSA：50.94000
- Density:1.3 g/cm3
- LogP:3.66290
- Storage Temp.:0-6°C
- Water Solubility.:17 mg l-1(20 °C)
- XLogP3:3.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:6
- Exact Mass:313.0748676
- Heavy Atom Count:20
- Complexity:308
- Purity/Quality:
-
99% *data from raw suppliers
Hexaconazol
PESTANAL *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn, 
N
- Hazard Codes:Xn;N,N,Xn
- Statements:
22-43-51/53
- Safety Statements:
2-24-37-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O
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Description
Hexaconazole is a kind of broad-spectrum systemic trazole fungicide. It can be used for the treatment of many kind of fungi diseases caused by ascomycetes, basidiomycetes, and imperfect fungi. It is especially suitable for the treatment of fungi diseases such as powdery mildew, rust, scab, brown blotch and anthracnose caused by ascomycetes and basidiomycetes. In China, India and some other Asian countries, it is mainly used for the control of rice sheath blight. It is applicable to apples, grapes, bananas, vegetables, peanuts, and cereal crops as well as ornament plants. Its mechanism of action is through inhibiting the biosynthesis of ergosterol (a key component of the fungi membrane) of fungi. Hexaconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. It is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L. It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively). Exogenous application of hexaconazole (15 mg/L) to M. chamomilla plants improves water, proline, and protein contents as well as increases non-enzymatic and enzymatic antioxidant and apigenin-7-glucoside content during a water deficit stress tolerance test. Hexaconazole inhibits the differentiation of mouse embryonic stem cells into cardiomyocytes (EC50 = 16.6 μM). It also induces bone morphological defects in mouse fetuses when administered to pregnant adult females during gestation.
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Uses
Hexaconazole is a systematic fungicide of the triazole class. Hexaconazole has a broad spectrum antifungal activity and is commonly used in the control of apple, coffee and peanut diseases. Agricultural fungicide. Hexaconazole is a systemic fungicide used for the control of
many fungi, particularly Ascomycetes and Basidiomycetes on a variety
of crops. It controls powdery mildews, scabs and rusts of vines, pome
fruits, vegetables and major diseases of small grain cereals.
