58905-16-1

Basic information

• Product Name: 1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE
• Synonyms: 1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE;2',4'-DICHLORO-2-(1,2,4 TRIAZOL-1YL) ACETOPHENONE;Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-;1-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
• CAS NO: 58905-16-1
• Molecular Formula: C₁₀H₇Cl₂N₃O
• Molecular Weight: 256.09
• Mol File: 58905-16-1.mol
• Article Data: 51

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 428.5°C at 760 mmHg
• Flash Point: 213°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 1.5E-07mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 2.03±0.10(Predicted)
• CAS DataBase Reference: 1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(58905-16-1)
• EPA Substance Registry System: 1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(58905-16-1)

Safety Data

• Hazardous Substances Data: 58905-16-1(Hazardous Substances Data)

Usage

Uses

1-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is an intermediate in the synthesis of Propiconazole (P770100) related compounds.

InChI:InChI=1/C10H7Cl2N3O/c11-7-1-2-8(9(12)3-7)10(16)4-15-6-13-5-14-15/h1-3,5-6H,4H2

Upstream product

• 56-84-8 L-Aspartic acid 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 2440-60-0 2-methyl-isourea 
• 288-88-0 1,2,4-Triazole 
• 2631-72-3 2,4-dichlorophenacyl bromide 
• 60207-90-1 Propiconazole 
• 95209-24-8 1-(2,4-dichlorophenyl)-1-oximino-2-(1,2,4-triazol-1-yl)-ethane 
• 1875-92-9 N,N-dimethylbenzylamine hydrochloride 
• 74-88-4 methyl iodide 
• 95-50-1 1,2-dichloro-benzene 
• 905807-90-1 1-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-yl-piperazine 
• 541-73-1 1,3-Dichlorobenzene 
• 584-13-4 4-amino-1,2,4-triazole 
• 4252-78-2 2,2',4'-trichloroacetophenone 

Downstream Products

• 81886-52-4 2-(2,4-dichlorophenyl)-1,3-di(1H-1,2,4-triazolyl)-2-propanol 
• 159382-00-0 4-[(Z)-3-(2,4-Dichloro-phenyl)-3-oxo-2-[1,2,4]triazol-1-yl-propenyl]-benzaldehyde 
• 154003-23-3 (2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-4-tozyloxymethyl-1,3-dioxolane 
• 113770-65-3 (2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-4-tozyloxymethyl-1,3-dioxolane 
• 132507-95-0 1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane 
• 154003-22-2 (-)-(2S,cis)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol 4-methylbenzenesulfonate (ester) 4-methylbenzenesulfonate 
• 96344-38-6 1-(2,4-dichlorophenyl)-1-oximino-2-(1,2,4-triazol-1-yl)-ethane 
• 95209-24-8 1-(2,4-dichlorophenyl)-1-oximino-2-(1,2,4-triazol-1-yl)-ethane 
• 63399-13-3 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-1H-1,2,4-triazole 
• 1395882-33-3 C₂₈H₂₆Cl₃FN₆O₄ 
• 117857-45-1 loreclezole 
• 67914-84-5 cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol benzoate (ester) 
• 172587-60-9 (-)-(2S,cis)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol 

Relevant articles and documents

Phototransformation of propiconazole in aqueous media

The photolysis of propiconazole in pure water, in water containing humic substances, and in natural water was investigated. The reaction rates were determined, and the main photoproducts were identified with the help of HPLC-mass spectrometry and by NMR.

Triazole compound containing dioxolame and preparation method of intermediate of triazole compound

The invention relates to a preparation method of a dioxolane-containing triazole compound and an intermediate thereof, and the method comprises the following steps: reacting a compound shown as a formula (V) with a compound shown as a formula (IV) in the presence of Lewis acid to prepare a compound shown as a formula (III); reacting the compound shown in the formula (III) with a compound shown in the formula (II) to prepare the compound shown in the formula (I). According to the technical scheme, a triazole group is introduced into 1H-1, 2, 4-triazole-1-acetic acid, generation of an isomer 1, 3, 4-triazole byproduct is avoided, the reaction yield is increased, and the method has the advantages of being simple and convenient in process route, few in reaction step, simple in process, low in production cost, environmentally friendly, green and safe; the post-treatment of the product only needs a simple solvent crystallization process, a nitric acid salifying method and a high-temperature distillation method do not need to be adopted, the requirements on equipment are reduced and the cost is reduced under the condition of improving the yield and content of the product, and the method is suitable for industrial production.

Design and Synthesis of Tetrazole- And Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

Itraconazole, a widely used antifungal drug, was found to possess antiangiogenic activity and is currently undergoing multiple clinical trials for the treatment of different types of cancer. However, it suffers from extremely low solubility and strong interactions with many drugs through inhibition of CYP3A4, limiting its potential as a new antiangiogenic and anticancer drug. To address these issues, a series of analogs in which the phenyl group is replaced with pyridine or fluorine-substituted benzene was synthesized. Among them the pyridine- and tetrazole-containing compound 24 has significantly improved solubility and reduced CYP3A4 inhibition compared to itraconazole. Similar to itraconazole, compound 24 inhibited the AMPK/mTOR signaling axis and the glycosylation of VEGFR2. It also induced cholesterol accumulation in the endolysosome and demonstrated binding to the sterol-sensing domain of NPC1 in a simulation study. These results suggested that compound 24 may serve as an attractive candidate for the development of a new generation of antiangiogenic drug.

insecticide compositions, insecticidal products containing them and methods of eradicating pests using them

Styryltriazole compounds having activity as antiparasitic hormone antagonists. Provided are an insecticide composition comprising an isomer or a pharmaceutically acceptable salt thereof, an insecticide product comprising the same, and a method for combating pests using the same.