5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

Base Information

Chemical Name:5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine
CAS No.:187850-59-5
Molecular Formula:C₁₉H₁₉N₃O₂S
Molecular Weight:353.445
Hs Code.:

Synonyms:5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

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Chemical Property of 5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

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Technology Process of 5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

There total 5 articles about 5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 591-50-4
iodobenzene

: 187850-59-5
5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 29 percent / PdCl₂(CH₃CN)2 / various solvent(s) / 16 h / Ambient temperature

2: 57 percent / Ph₃PBr₂ / acetonitrile / 5 h / Heating

3: 1) t-BuOK, 18-crown-6 / 1) THF, reflux, 1.5 h, 2) THF, reflux, 9 h

4: HCl / diethyl ether

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; triphenylphosphine dibromide 1:1 addition complex; dichloro bis(acetonitrile) palladium(II); In diethyl ether; acetonitrile;
DOI:10.1021/ja963114c

Reference yield:

: 3,4-Bis-methoxymethyl-1-(toluene-4-sulfonyl)-2-trimethylstannanyl-1H-pyrrole

: 187850-59-5
5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 29 percent / PdCl₂(CH₃CN)2 / various solvent(s) / 16 h / Ambient temperature

2: 57 percent / Ph₃PBr₂ / acetonitrile / 5 h / Heating

3: 1) t-BuOK, 18-crown-6 / 1) THF, reflux, 1.5 h, 2) THF, reflux, 9 h

4: HCl / diethyl ether

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; triphenylphosphine dibromide 1:1 addition complex; dichloro bis(acetonitrile) palladium(II); In diethyl ether; acetonitrile;
DOI:10.1021/ja963114c