3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole

Base Information

• Chemical Name: 3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole
• CAS No.: 187850-50-6
• Molecular Formula: C₂₁H₂₃NO₄S
• Molecular Weight: 385.484
• Mol file: 187850-50-6.mol

Synonyms:3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole

Chemical Property of 3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole

There total 1 articles about 3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

iodobenzene (591-50-4) + 3,4-Bis-methoxymethyl-1-(toluene-4-sulfonyl)-2-trimethylstannanyl-1H-pyrrole → 3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole (187850-50-6)

Guidance literature:

dichloro bis(acetonitrile) palladium(II); In various solvent(s); for 16h; Ambient temperature;

DOI:10.1021/ja963114c

Reference yield: 57.0%

3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole (187850-50-6) → 3,4-Bis-bromomethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole (187850-56-2)

Guidance literature:

With triphenylphosphine dibromide 1:1 addition complex; In acetonitrile; for 5h; Heating;

DOI:10.1021/ja963114c

Reference yield:

3,4-Bis-methoxymethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole (187850-50-6) → 5-Phenyl-6-(toluene-4-sulfonyl)-4,6-dihydro-1H-pyrrolo[3,4-d]pyridazine

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / Ph₃PBr₂ / acetonitrile / 5 h / Heating

2: 1) t-BuOK, 18-crown-6 / 1) THF, reflux, 1.5 h, 2) THF, reflux, 9 h

3: HCl / diethyl ether

4: dimethyl azodicarboxylate / -30 °C

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; dimethyl azodicarboxylate; triphenylphosphine dibromide 1:1 addition complex; In diethyl ether; acetonitrile;

DOI:10.1021/ja963114c

upstream raw materials:

iodobenzene

Downstream raw materials:

3,4-Bis-bromomethyl-2-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole

5-Phenyl-6-(toluene-4-sulfonyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyridazine

5-Phenyl-6-(toluene-4-sulfonyl)-4,6-dihydro-1H-pyrrolo[3,4-d]pyridazine-2,3-dicarboxylic acid di-tert-butyl ester