3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

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Chemical Name:3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester
CAS No.:845784-44-3
Molecular Formula:C₄₀H₃₆Br₂N₂O₇
Molecular Weight:816.543
Hs Code.:

Synonyms:3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

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Chemical Property of 3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

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Technology Process of 3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

There total 11 articles about 3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 3-(4-Benzyloxy-3-{4-[2-[(Z)-benzyloxyimino]-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,6-dibromo-phenoxy}-phenyl)-2-[(E)-benzyloxyimino]-propionic acid methyl ester

: 845784-44-3
3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

: 845784-45-4
3-[4-Benzyloxy-3-(4-{2-[(Z)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/chem.200400904

Reference yield:

: 705932-33-8
4-benzyloxy-3-[2,6-dibromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde

: 845784-44-3
3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 97 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

2.1: 83 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

3.1: 87 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

4.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

4.2: 88 percent / dimethylformamide / 12 h / 0 - 20 °C

5.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

6.1: 89 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

7.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

8.1: pyridine / ethanol / 20 °C

9.1: 11 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; n-Butyl nitrite; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Knoevenagel condensation;
DOI:10.1002/chem.200400904

Reference yield:

: 845784-36-3
2-{4-benzyloxy-3-[2,6-dibromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzylidene}-malonic acid dimethyl ester

: 845784-44-3
3-[4-Benzyloxy-3-(4-{2-[(E)-benzyloxyimino]-3-hydroxy-propyl}-2,6-dibromo-phenoxy)-phenyl]-2-[(E)-benzyloxyimino]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 83 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

2.1: 87 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

3.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

3.2: 88 percent / dimethylformamide / 12 h / 0 - 20 °C

4.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

5.1: 89 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

6.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

7.1: pyridine / ethanol / 20 °C

8.1: 11 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; n-Butyl nitrite; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.200400904