tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

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Chemical Name:tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate
CAS No.:1427309-42-9
Molecular Formula:C₃₁H₄₈ClF₂N₃O₃
Molecular Weight:584.19
Hs Code.:

Synonyms:tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

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Chemical Property of tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

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Technology Process of tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

There total 19 articles about tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.2%

: 1427058-75-0
2-(bromomethyl)-1-chloro-3-(difluoromethyl)benzene

: 1427309-41-8
tert-butyl 2-[(3S,4R)-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

: 1427309-42-9
tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 99586-84-2
methyl 2-methyl-3-chlorobenzoate

: 1427309-42-9
tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3.45 h / 90 °C

2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 20 °C

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With manganese(IV) oxide; N-Bromosuccinimide; diisobutylaluminium hydride; potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; dibenzoyl peroxide; In tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1427309-40-7
tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

: 1427309-42-9
tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 2 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With 20% palladium hydroxide-activated charcoal; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;