tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Base Information

Chemical Name:tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate
CAS No.:1427309-40-7
Molecular Formula:C₃₀H₄₇Cl₂N₃O₃
Molecular Weight:568.627
Hs Code.:

Synonyms:tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

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Chemical Property of tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

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Technology Process of tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

There total 13 articles about tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 2-[(3RS,4SR)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

: tert-butyl 2-[(3R,4S)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

: 1427309-40-7
tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: With CHIRALPAK IA; In ethanol; hexane; at 40 ℃; Resolution of racemate;

Reference yield:

: tert-butyl 2-[(3RS,4SR)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

: 1427309-40-7
tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: With CHIRALPAK IA; In ethanol; hexane; Resolution of racemate;

Reference yield:

: C₁₉H₂₇NO₄

: 1427309-40-7
tert-butyl 2-[(3S,4R)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / methanol / 20 - 50 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

3: CHIRALPAK IA / hexane; ethanol / 40 °C / Resolution of racemate

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In methanol; ethanol; hexane; N,N-dimethyl-formamide;