Z-L-phenylalanyl-L-alanyl bromomethyl ketone

Base Information

• Chemical Name: Z-L-phenylalanyl-L-alanyl bromomethyl ketone
• CAS No.: 115186-22-6
• Molecular Formula: C₂₁H₂₃BrN₂O₄
• Molecular Weight: 447.329
• Mol file: 115186-22-6.mol

Synonyms:Z-L-phenylalanyl-L-alanyl bromomethyl ketone

Chemical Property of Z-L-phenylalanyl-L-alanyl bromomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-L-phenylalanyl-L-alanyl bromomethyl ketone

There total 2 articles about Z-L-phenylalanyl-L-alanyl bromomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-benzyloxycarbonyl-L-phenylalanyl-L-alanine (3338-39-4,16088-00-9,16088-38-3,17563-25-6,55387-02-5,80996-16-3,21881-18-5) → Z-L-phenylalanyl-L-alanyl bromomethyl ketone (115186-22-6)

Guidance literature:

With hydrogen bromide; isobutyl chloroformate; Yield given. Multistep reaction;

DOI:10.1021/ja954261y

Reference yield:

(Z,3S)-1-diazonio-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]but-1-en-2-olate carbamic acid (71732-53-1) → Z-L-phenylalanyl-L-alanyl bromomethyl ketone (115186-22-6)

Guidance literature:

With hydrogen bromide; acetic acid; In dichloromethane; at 0 ℃; for 0.0166667h;

DOI:10.1016/j.bmc.2010.07.041

Reference yield:

2,6-dimethylbenzoic acid (632-46-2) + Z-L-phenylalanyl-L-alanyl bromomethyl ketone (115186-22-6) → 2,6-Dimethyl-benzoic acid (S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-butyl ester

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 21 ℃;

DOI:10.1021/ja00221a062

upstream raw materials:

diazomethane

N-benzyloxycarbonyl-L-phenylalanyl-L-alanine

(Z,3S)-1-diazonio-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]but-1-en-2-olate carbamic acid