Welcome to LookChem.com Sign In|Join Free

CAS

  • or

632-46-2

Post Buying Request

632-46-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

632-46-2 Usage

Uses

Different sources of media describe the Uses of 632-46-2 differently. You can refer to the following data:
1. 2,6-Dimethylbenzoic acid is a benzoic acid derivative used in the preparation of antiinflammatory and antirheumatic agents. And it is also a potential geothermal tracer.
2. Benzoic acid derivative used in the preparation of antiinflammatory and antirheumatic agents. A potential geothermal tracer.

Definition

ChEBI: A dimethylbenzoic acid in which the two methyl groups are located at positions 2 and 6.

General Description

Crystal structure of 2,6-dimethylbenzoic acid was studied by three-dimensional X-ray methods.

Purification Methods

Steam distil the acid, and crystallise it from EtOH or H2O (m 116.3-116.7o). The N-dimethylamide has m 62-63o (from Et2O). [Beilstein 9 H 531, 9 IV 1798.]

Check Digit Verification of cas no

The CAS Registry Mumber 632-46-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 632-46:
(5*6)+(4*3)+(3*2)+(2*4)+(1*6)=62
62 % 10 = 2
So 632-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O2/c1-6-4-3-5-7(2)8(6)9(10)11/h3-5H,1-2H3,(H,10,11)

632-46-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A15014)  2,6-Dimethylbenzoic acid, 98+%   

  • 632-46-2

  • 1g

  • 262.0CNY

  • Detail
  • Alfa Aesar

  • (A15014)  2,6-Dimethylbenzoic acid, 98+%   

  • 632-46-2

  • 5g

  • 846.0CNY

  • Detail
  • Alfa Aesar

  • (A15014)  2,6-Dimethylbenzoic acid, 98+%   

  • 632-46-2

  • 25g

  • 3588.0CNY

  • Detail

632-46-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-dimethylbenzoic acid

1.2 Other means of identification

Product number -
Other names Benzoic acid, 2,6-dimethyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:632-46-2 SDS

632-46-2Synthetic route

4-methoxybenzyl 2,6-dimethylbenzoate

4-methoxybenzyl 2,6-dimethylbenzoate

ethylene glycol
107-21-1

ethylene glycol

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

2-(4-methoxybenzyloxy)ethanol
13807-89-1

2-(4-methoxybenzyloxy)ethanol

Conditions
ConditionsYield
at 140℃; for 4h;A 96%
B n/a
carbon dioxide
124-38-9

carbon dioxide

2-Bromo-m-xylene
576-22-7

2-Bromo-m-xylene

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
Stage #1: 2-Bromo-m-xylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 20℃;
93.2%
Stage #1: 2-Bromo-m-xylene With ethyl bromide; magnesium In diethyl ether Grignard reaction; Inert atmosphere; Reflux;
Stage #2: carbon dioxide In diethyl ether at 20℃; Grignard reaction; Inert atmosphere;
54%
(i) Mg, (ii) /BRN= 1900390/; Multistep reaction;
(i) Mg, EtBr, Et2O, (ii) /BRN= 1900390/; Multistep reaction;
carbon dioxide
124-38-9

carbon dioxide

2,6-dimethylbenzene boronic acid
100379-00-8

2,6-dimethylbenzene boronic acid

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); potassium methanolate In tetrahydrofuran at 70℃; for 24h; Schlenk technique; Sealed tube;88%
2,6-dimethylphenyl trifluoromethanesulphonate
86364-02-5

2,6-dimethylphenyl trifluoromethanesulphonate

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 50℃; for 12h; Schlenk technique; Inert atmosphere; chemoselective reaction;82%
2,6-dimethyl-N-(quinolin-8-yl)benzamide
1609401-42-4

2,6-dimethyl-N-(quinolin-8-yl)benzamide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With sulfuric acid; water at 120℃; for 24h;80%
2,6-dimethylphenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,6-dimethylphenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 50℃; for 12h; Schlenk technique; Inert atmosphere; chemoselective reaction;79%
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; silver carbonate; p-benzoquinone; palladium diacetate In tert-butyl alcohol at 100℃; for 3h;75%
carbon dioxide
124-38-9

carbon dioxide

C10H14Si

C10H14Si

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide With bis(1,5-cyclooctadiene)nickel (0); 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene In 1,3,5-trimethyl-benzene at 20℃; under 760.051 Torr; for 0.166667h; Schlenk technique;
Stage #2: C10H14Si In 1,3,5-trimethyl-benzene at 160℃; for 20h; Schlenk technique;
58%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

sodium o-toluate
17264-71-0

sodium o-toluate

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With silver carbonate; p-benzoquinone; palladium diacetate In tert-butyl alcohol at 100℃; for 3h;50%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

2-methylbenzoic acid potassium salt
16463-31-3

2-methylbenzoic acid potassium salt

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With silver carbonate; p-benzoquinone; palladium diacetate In tert-butyl alcohol at 100℃; for 3h;48%
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

di-tert-butyl peroxide
110-05-4

di-tert-butyl peroxide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With potassium acetate; palladium diacetate at 80℃; under 760.051 Torr; for 24h;48%
With potassium acetate; palladium diacetate at 80℃; for 24h; Schlenk technique;48%
2-fluoro-m-xylene
443-88-9

2-fluoro-m-xylene

carbon dioxide
124-38-9

carbon dioxide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-m-xylene With C78H70Al2Cl4N6P4Rh2; magnesium; ethylene dibromide In tetrahydrofuran at 50℃; for 22h; Inert atmosphere; Glovebox;
Stage #2: carbon dioxide In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.5h;
48%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

2,3-dimethylbenzoic acid
603-79-2

2,3-dimethylbenzoic acid

Conditions
ConditionsYield
With air; acetic acid; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione; cobalt(II) acetate; manganese(II) acetate at 100℃; under 760 Torr; for 1h;A 13%
B 36%
carbon monoxide
201230-82-2

carbon monoxide

2,6-dimethylbenzenediazonium tetrafluoroborate
2192-33-8

2,6-dimethylbenzenediazonium tetrafluoroborate

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

N-(2,6-dimethylphenyl)acetamide
2198-53-0

N-(2,6-dimethylphenyl)acetamide

C

2,6-Dimethylbenzoic anhydride
73368-14-6

2,6-Dimethylbenzoic anhydride

Conditions
ConditionsYield
With sodium acetate; palladium diacetate In acetonitrile under 6619.6 Torr; for 1h; Ambient temperature;A 28%
B 16%
C 3%
2,5-dimethylbenzamide
55321-98-7

2,5-dimethylbenzamide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With phosphoric acid at 145 - 150℃;
4-amino-2,6-dimethyl benzoic acid
16752-16-2

4-amino-2,6-dimethyl benzoic acid

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
Diazotization.Reaktion ueber mehrere Stufen;
2,2,2-trichloro-1-(2,6-dimethyl-phenyl)-ethanone
99184-32-4

2,2,2-trichloro-1-(2,6-dimethyl-phenyl)-ethanone

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

(2,6-dimethyl-phenyl)-hydroxy-acetic acid
99186-43-3

(2,6-dimethyl-phenyl)-hydroxy-acetic acid

Conditions
ConditionsYield
With sodium hydroxide
(2,6-dimethyl-benzyl)-dimethyl-amine
54521-25-4

(2,6-dimethyl-benzyl)-dimethyl-amine

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; potassium permanganate
2,6-dimethylbenzoyl chloride
21900-37-8

2,6-dimethylbenzoyl chloride

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With water In acetone at -20℃; Rate constant;
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
1) diazotation; Multistep reaction;
Multi-step reaction with 2 steps
1: (i) (diazotization), aq. HBr, (ii) Cu
2: (i) Mg, (ii) /BRN= 1900390/
View Scheme
Multi-step reaction with 2 steps
1: (i) NaNO2, aq. HBr, (ii) CuBr
2: (i) Mg, EtBr, Et2O, (ii) /BRN= 1900390/
View Scheme
Multi-step reaction with 2 steps
1: (i) NaNO2, aq. HCl, (ii) /BRN= 4652394/, CuSO4, aq. NH3, benzene
2: aq. H2SO4 / Heating
View Scheme
bis(2,6-dimethylbenzoyl) peroxide
96436-29-2

bis(2,6-dimethylbenzoyl) peroxide

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

m-xylene
108-38-3

m-xylene

C

2,6-dimethylphenyl 2,6-dimethylbenzoate

2,6-dimethylphenyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With 2,4,6-tri-tert-butylphenoxol In acetonitrile Ambient temperature; Irradiation; laser flash photolyses with 308-nm laser puses; Yield given. Yields of byproduct given;
With 2,4,6-tri-tert-butylphenoxol In acetonitrile Ambient temperature; Irradiation; Yield given. Yields of byproduct given;
In acetonitrile Product distribution; Mechanism; Irradiation; in the presence or absence of 2,4,6-tri-tert-butylphenol and/or dibenzoyl peroxide; structural and solvent effect upon decarboxylation investigated of various 2,6-disubstituited benzoyloxy radicals;
ethanol
64-17-5

ethanol

2,6-dimethylbenzoyl chloride
21900-37-8

2,6-dimethylbenzoyl chloride

A

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

B

2,6-dimethylbenzoic acid ethyl ester
36596-67-5

2,6-dimethylbenzoic acid ethyl ester

Conditions
ConditionsYield
With water at 10℃; Kinetics; Thermodynamic data; Product distribution; solvolysis examined; var. solvents and ratio of ones; mechanism; ΔH(excit.), ΔS(excit.);
2,6-dimethyliodobenzene
608-28-6

2,6-dimethyliodobenzene

carbon dioxide
124-38-9

carbon dioxide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
(i) Mg, EtBr, I2, (ii) /BRN= 1900390/; Multistep reaction;
2,6-dimethylbenzonitrile
6575-13-9

2,6-dimethylbenzonitrile

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With sulfuric acid Heating;
Multi-step reaction with 2 steps
1: concentrated sulfuric acid / 75 - 80 °C
2: phosphoric acid / 145 - 150 °C
View Scheme
4-chloro-2,6-dimethyl benzoic acid
35887-72-0

4-chloro-2,6-dimethyl benzoic acid

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; nickel
methanol
67-56-1

methanol

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

A

7-methyl-3H-isobenzofuran-1-one
2211-84-9

7-methyl-3H-isobenzofuran-1-one

B

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

C

2-Methoxymethyl-6-methylbenzoesaeure

2-Methoxymethyl-6-methylbenzoesaeure

Conditions
ConditionsYield
With sodium hydroxide; N-Bromosuccinimide 1.) CCl4, reflux, 3 h, irradiation, 2.) reflux, 35 h; Yield given. Multistep reaction. Yields of byproduct given;
methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

2,6-dimethyl-phenyl magnesium bromide

2,6-dimethyl-phenyl magnesium bromide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

2,6-dimethyl-phenyl magnesium iodide

2,6-dimethyl-phenyl magnesium iodide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

diazotized 2-amino-m-xylene

diazotized 2-amino-m-xylene

potassium cuprocyanide

potassium cuprocyanide

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

Conditions
ConditionsYield
durch Verseifung;
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,6-dimethylbenzyl alcohol
62285-58-9

2,6-dimethylbenzyl alcohol

Conditions
ConditionsYield
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran for 72h; Ambient temperature;100%
Stage #1: 2,6-dimethylbenzoic acid With borane-THF In tetrahydrofuran at 0 - 20℃; for 64.3333h;
Stage #2: With methanol In tetrahydrofuran
99%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 64.3h;99%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;100%
With potassium carbonate In acetone at 20℃; for 4h;93%
With potassium hydroxide
With potassium carbonate at 25℃; for 1h;
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

methylamine
74-89-5

methylamine

2,6-dimethyl-N-methylbenzamide
223554-22-1

2,6-dimethyl-N-methylbenzamide

Conditions
ConditionsYield
100%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

C82H102N4O28Pt8

C82H102N4O28Pt8

C124H138N4O28Pt8

C124H138N4O28Pt8

Conditions
ConditionsYield
In methanol; dichloromethane at 20℃; for 6h;100%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C9H9O2(1-)*C4H12N(1+)

C9H9O2(1-)*C4H12N(1+)

Conditions
ConditionsYield
With water In ethanol at 0 - 20℃; for 0.0833333h;100%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

1-ethoxyacetylene
927-80-0

1-ethoxyacetylene

2,6-Dimethyl-benzoic acid 1-ethoxy-vinyl ester

2,6-Dimethyl-benzoic acid 1-ethoxy-vinyl ester

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In toluene at 0 - 20℃; for 5h;99.9%
norborn-2-ene
498-66-8

norborn-2-ene

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

C8H11O2C6H5CH2CH2

C8H11O2C6H5CH2CH2

Conditions
ConditionsYield
silver trifluoromethanesulfonate; iron(III) chloride In 1,2-dichloro-ethane at 80℃;99%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

diphenyl acetylene
501-65-5

diphenyl acetylene

C23H20O2

C23H20O2

Conditions
ConditionsYield
With [{Au(IPr)}2(μ-OH)][BF4] In neat (no solvent) at 80℃; for 15h; regioselective reaction;99%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,6-dimethyl-3-nitrobenzoic acid
6307-70-6

2,6-dimethyl-3-nitrobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0℃; for 1.5h;98%
With sulfuric acid; nitric acid at 0℃; for 1h;
With nitric acid; acetic acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

cyanoacetic acid
372-09-8

cyanoacetic acid

cyanomethyl 2,6-dimethylbenzoate

cyanomethyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; sodium acetate; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; water at 80℃; for 12h;98%
With tert.-butylhydroperoxide; sodium acetate; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; water at 80℃; for 12h;96%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;97%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 5h; Inert atmosphere;95%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere;89%
styrene
292638-84-7

styrene

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2-bromo-1-phenylethyl 2,6-dimethylbenzoate

2-bromo-1-phenylethyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With C19H27NO2 In n-heptane at 23℃; Darkness; Green chemistry;97%
With N-Bromosuccinimide; C25H44NO2PS In chloroform at 25℃; for 20h; Darkness; regioselective reaction;90%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

N-Cyclohexyl-2-hydroxy-2-(S)-pyrrolidin-2-yl-acetamide; hydrochloride

N-Cyclohexyl-2-hydroxy-2-(S)-pyrrolidin-2-yl-acetamide; hydrochloride

N-cyclohexyl-(RS)-2-hydroxy-2-{(S)-2-[1-(2,6-dimethylbenzoyl)pyrrolidinyl]}acetamide

N-cyclohexyl-(RS)-2-hydroxy-2-{(S)-2-[1-(2,6-dimethylbenzoyl)pyrrolidinyl]}acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide Ambient temperature;96.3%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,6-dimethylcyclohexa-2,5-diene-1-carboxylic acid
31673-42-4

2,6-dimethylcyclohexa-2,5-diene-1-carboxylic acid

Conditions
ConditionsYield
With ammonia; sodium In ethanol at -50℃; Birch reduction;96%
With tert-Amyl alcohol; lithium In tetrahydrofuran; ammonia Birch Reduction; Reflux; liquid NH3;90%
With N,N'-Dimethylurea; tris(pyrrolidino)phosphine oxide; lithium bromide In tetrahydrofuran Electrochemical reaction;90%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,6-Dimethylbenzoic anhydride
73368-14-6

2,6-Dimethylbenzoic anhydride

Conditions
ConditionsYield
With 2,6-dimethylpyridine; tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide; N,N-dimethyl-formamide at 25 - 30℃; for 12h; Inert atmosphere; Photolysis;96%
With potassium carbonate; p-toluenesulfonyl chloride In dichloromethane; acetonitrile at 20℃; for 48h;94%
With copper(II) bis(trifluoromethanesulfonate) at 80℃; for 0.5h;81%
ethanol
64-17-5

ethanol

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,6-dimethylbenzoic acid ethyl ester
36596-67-5

2,6-dimethylbenzoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 12h; Sealed tube;95%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

(R)-[1-(naphthalen-2-yl)ethyl]amine
1201-74-7, 3082-62-0, 3906-16-9, 64234-21-5

(R)-[1-(naphthalen-2-yl)ethyl]amine

2,6-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
1184301-95-8

2,6-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 23℃; Combinatorial reaction / High throughput screening (HTS); Inert atmosphere;94%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

propionyl chloride
79-03-8

propionyl chloride

2,6-dimethylbenzoic propionic anhydride

2,6-dimethylbenzoic propionic anhydride

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;94%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2,3-dimethyl-N-(quinolin-8-yl)benzamide

2,3-dimethyl-N-(quinolin-8-yl)benzamide

3,4-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,6-dimethylbenzoate

3,4-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With silver carbonate; cobalt acetylacetonate In 1,2-dichloro-ethane at 100℃; for 3h;94%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With tributyl-amine In N,N-dimethyl-formamide at 285℃; under 112511 Torr; for 0.05h;93%
With sulfuric acid at 80 - 85℃; for 8h; Neat (no solvent);74.5%
1-ethenyl-4-methylbenzene
622-97-9

1-ethenyl-4-methylbenzene

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2-bromo-1-(p-tolyl)ethyl 2,6-dimethylbenzoate

2-bromo-1-(p-tolyl)ethyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With C19H27NO2 In n-heptane at 23℃; Darkness; Green chemistry;93%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

3-methoxy-2-methyl-N-(quinolin-8-yl)benzamide

3-methoxy-2-methyl-N-(quinolin-8-yl)benzamide

4-methoxy-3-methyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,6-dimethylbenzoate

4-methoxy-3-methyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With silver carbonate; cobalt acetylacetonate In 1,2-dichloro-ethane at 100℃; for 3h;92%
4-vinylbenzyl chloride
1073-67-2

4-vinylbenzyl chloride

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2-bromo-1-(4-chlorophenyl)ethyl 2,6-dimethylbenzoate

2-bromo-1-(4-chlorophenyl)ethyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With C19H27NO2 In n-heptane at 23℃; Darkness; Green chemistry;92%
alpha-D-glucopyranose
492-62-6

alpha-D-glucopyranose

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

1-O-(2,6-dimethylbenzoyl)-β-D-glucopyranoside

1-O-(2,6-dimethylbenzoyl)-β-D-glucopyranoside

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In 1,4-dioxane at 20℃; for 0.5h; Mitsunobu Displacement; Inert atmosphere; stereoselective reaction;92%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

C21H38BrN3O4

C21H38BrN3O4

C30H47N3O6

C30H47N3O6

Conditions
ConditionsYield
With potassium fluoride In acetonitrile at 20℃; for 12h; Cooling with ice;91%
1-bromo-4-ethenyl-benzene
2039-82-9

1-bromo-4-ethenyl-benzene

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

2-bromo-1-(4-bromophenyl)ethyl 2,6-dimethylbenzoate

2-bromo-1-(4-bromophenyl)ethyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With C19H27NO2 In n-heptane at 23℃; Darkness; Green chemistry;91%
Methyl trichloroacetate
598-99-2

Methyl trichloroacetate

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate at 90 - 150℃; for 2h;90%
1,4-dioxane
123-91-1

1,4-dioxane

2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

C13H16O4
1284251-40-6

C13H16O4

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 80℃; for 12h;90%

632-46-2Relevant articles and documents

Treffers,Hammett

, p. 1708,1709 (1937)

Magnesiation of Aryl Fluorides Catalyzed by a Rhodium-Aluminum Complex

Fujii, Ikuya,Semba, Kazuhiko,Li, Qiao-Zhi,Sakaki, Shigeyoshi,Nakao, Yoshiaki

supporting information, p. 11647 - 11652 (2020/08/06)

We report the magnesiation of aryl fluorides catalyzed by an Al-Rh heterobimetallic complex. We show that the complex is highly reactive to cleave the C-F bonds across the polarized Al-Rh bond under mild conditions. The reaction allows the use of an easy-to-handle magnesium powder to generate a range of arylmagnesium reagents from aryl fluorides, which are conventionally inert to such metalation compared with other aryl halides.

Method for copper-catalyzed carboxylation reaction of arylboronic acid and carbon dioxide

-

Paragraph 0087; 0088, (2019/12/29)

The invention discloses a method for a copper-catalyzed carboxylation reaction of arylboronic acid and carbon dioxide. According to the method, carbon dioxide is used as a C1 source, copper catalysisis adopted, alkoxide serves as alkali, and a reaction is carried out in an organic solvent; the method is simple in process and easy to implement, and shows wide functional group compatibility; the method allows various arylboronic acids such as monosubstituted or polysubstituted phenylboronic acid, polycyclic aromatic hydrocarbon boronic acid and benzoheterocyclic boronic acid to be converted into corresponding arylcarboxylic acids with considerable yield under mild conditions; and the produced carboxylic acids have important application value, and can be used for deriving a great number of other common chemical substances, such as acyl halide, acid anhydride, ester and amide.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 632-46-2