3-(pyridin-4-yl)cyclohexanone

Base Information

• Chemical Name: 3-(pyridin-4-yl)cyclohexanone
• CAS No.: 115444-30-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 115444-30-9.mol

Synonyms:3-(pyridin-4-yl)cyclohexan-1-one

Chemical Property of 3-(pyridin-4-yl)cyclohexanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Pyridinyl)cyclohexanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(pyridin-4-yl)cyclohexanone

There total 11 articles about 3-(pyridin-4-yl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cyclohexenone (930-68-7) + 4-pyridylboronic acid MIDA ester (1104636-72-7) → 3-(pyridin-4-yl)cyclohexan-1-one (115444-30-9)

Guidance literature:

With potassium phosphate; [Rh(OH)(cod)]2; In 1,4-dioxane; water; at 60 ℃; for 16h; Glovebox; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol502630w

Reference yield: 65.0%

cyclohexenone (930-68-7) + 4-pyridineboronic acid pinacol ester (181219-01-2) → 3-(pyridin-4-yl)cyclohexan-1-one (115444-30-9)

Guidance literature:

With [Rh(OH)(cod)]2; potassium carbonate; In water; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.1c00272

Reference yield: 53.0%

pyridine-4-carbonitrile (100-48-1) + cyclohexenone (930-68-7) → 3-(pyridin-4-yl)cyclohexan-1-one (115444-30-9)

Guidance literature:

With bis(acetylacetonate)nickel(II); tetrabutylammonium perchlorate; sodium carbonate; In 1,2-dichloro-ethane; acetonitrile; at 50 ℃; for 3h;

DOI:10.1021/acs.orglett.0c01014

upstream raw materials:

pyridine-4-carbonitrile

1-methoxy-cyclohex-1-ene

1-cyclohexenyl acetate

4-(3-cyclohexen-1-yl)pyridine

Downstream raw materials:

2-acetyl-5-(4-pyridyl)cyclohexanone