(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Base Information

Chemical Name:(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol
CAS No.:1255700-82-3
Molecular Formula:C₂₆H₂₈N₆O₃
Molecular Weight:472.547
Hs Code.:

Synonyms:(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Suppliers and Price of (R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

There total 7 articles about (R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1079178-13-4
5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-amine

: 1255701-48-4
(R)-2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

: 1255700-82-3
(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: With caesium carbonate; palladium diacetate; CyJohnPhos; at 100 ℃; for 1.75h; Inert atmosphere; Sealed microwave vial;

Reference yield:

: 41789-37-1
2,6-dichloro-5-pyridylmethyl chloride

: 1255700-82-3
(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

3.1: acetic acid / methanol / 0.25 h / 0 °C

3.2: 2.08 h / 20 °C

4.1: caesium carbonate / palladium diacetate; CyJohnPhos / 1.75 h / 100 °C / Inert atmosphere; Sealed microwave vial

With sodium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium diacetate; CyJohnPhos; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 75711-00-1
2-chloro-3-methoxy-5-nitropyridine

: 1255700-82-3
(R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 20 - 45 °C

2: sodium tetrahydroborate / nickel dichloride / methanol; dichloromethane / 20 °C

3: caesium carbonate / palladium diacetate; CyJohnPhos / 1.75 h / 100 °C / Inert atmosphere; Sealed microwave vial

With sodium tetrahydroborate; potassium carbonate; caesium carbonate; palladium diacetate; nickel dichloride; CyJohnPhos; In methanol; dichloromethane; dimethyl sulfoxide;