1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

Base Information

Chemical Name:1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin
CAS No.:116861-71-3
Molecular Formula:C₂₆H₂₆BrNO₄
Molecular Weight:496.401
Hs Code.:

Synonyms:1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

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Chemical Property of 1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

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Technology Process of 1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

There total 19 articles about 1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-3,4-dihydroisochinolinjodid

: 116861-71-3
1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

Guidance literature:: With sodium tetrahydroborate; In methanol; 1.) 50 deg C, 2.) room temp., 30 min;
DOI:10.1002/ardp.19883210308

Reference yield:

: C₂₆H₂₃BrNO₄⁽¹⁺⁾*I^(1-)

: C₂₆H₂₄BrNO₄

: 116861-71-3
1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

Guidance literature:: With methanol; sodium tetrahydroborate; at -78 ℃; for 0.0833333h; Temperature; Reagent/catalyst; Inert atmosphere;
DOI:10.1248/cpb.c20-00370

Reference yield:

: 38849-42-2
2-Brom-3-benzyloxy-4-methoxy-phenylessigsaeure

: 116861-71-3
1-(2'-Brom-3'-benzyloxy-4'-methoxy-benzyl)-2-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroisochinolin

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / NaHCO₃ / xylene / 16 h / Heating

2: 82 percent / POCl₃ / toluene / 3 h / Heating

3: 84 percent / 5percent aq. NH₃ / CHCl₃ / 15 h / Heating

4: 98 percent / 1.) NaBH₄ / methanol / 1.) 50 deg C, 2.) room temp., 30 min

With ammonium hydroxide; sodium tetrahydroborate; sodium hydrogencarbonate; trichlorophosphate; In methanol; chloroform; toluene; xylene;
DOI:10.1002/ardp.19883210308