1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose

Base Information

• Chemical Name: 1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose
• CAS No.: 83376-99-2
• Molecular Formula: C₂₉H₂₆O₉
• Molecular Weight: 518.52
• Mol file: 83376-99-2.mol

Synonyms:1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose

Chemical Property of 1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose

There total 1 articles about 1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + benzoyl chloride (98-88-4) + methyl 5-O-benzoyl-2,3-O-isopropylidene-6-deoxy-α-L-talofuranoside (28538-27-4) → 1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose (83376-99-2)

Guidance literature:

With pyridine; hydrogenchloride; acetic acid; Reagens 4: Schwefelsaeure;

DOI:10.1021/ja01554a046

Reference yield: 51.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose (83376-99-2) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → 1,3-bis(2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil (76821-32-4) + 1-(2,3,5-Tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil (76767-89-0) + 3-(2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil (76767-90-3)

Guidance literature:

With chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction;

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose (83376-99-2) + N2-acetylguanine (81126-73-0) → N2-acetyl-5'(S)-C-methyl-2',3',5'-O-tribenzoylguanosine (1246254-22-7)

Guidance literature:

N₂-acetylguanine; With 1,1,1,3,3,3-hexamethyl-disilazane; In pyridine; for 2h; Reflux; Inert atmosphere;

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranose; With trimethylsilyl trifluoromethanesulfonate; In toluene; at 20 ℃; Reflux; Inert atmosphere;

upstream raw materials:

acetic anhydride

benzoyl chloride

methyl 5-O-benzoyl-2,3-O-isopropylidene-6-deoxy-α-L-talofuranoside

Downstream raw materials:

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((S)-1-hydroxyethyl)tetrahydrofuran-3,4-diol

1,3-bis(2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil

1-(2,3,5-Tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil

3-(2,3,5-tri-O-benzoyl-6-deoxy-α-L-talofuranosyl)uracil