10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion

Base Information

• Chemical Name: 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion
• CAS No.: 63052-60-8
• Molecular Formula: C₁₉H₁₇N₃O₂S
• Molecular Weight: 351.429
• Mol file: 63052-60-8.mol

Synonyms:10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion

Chemical Property of 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion

There total 6 articles about 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-10H-pyrimido<5,4-b><1,4>benzothiazine (25861-95-4) + benzyl bromide (100-39-0) → 5-Benzyl-1,3-dimethyl-2-oxo-1,2,3,6-tetrahydro-(1H,3H)-pyrimido<5.4-b><1.4>benzothiazin-5-ium-4-olat (342605-76-9,63052-56-2) + 4a-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-4aH-pyrimido<5.4-b><2.4>benzothiazin-1,4(1H,3H)-dion (63052-57-3) + 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion (63052-60-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1002/ardp.19813141207

Reference yield:

1,3-dimethylbarbituric acid (769-42-6) → 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion (63052-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfoxide / 3 h / 130 °C

2: 8.5 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/ardp.19813141207

Reference yield:

2-amino-benzenethiol (137-07-5) → 10-Benzyl-1,3-dimethyl-10H-pyrimido<5.4-b><1.4>benzothiazin-2,4-(1H,3H)-dion (63052-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfoxide / 3 h / 130 °C

2: 8.5 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/ardp.19813141207

upstream raw materials:

5-Benzyl-1,3-dimethyl-2-oxo-1,2,3,6-tetrahydro-(1H,3H)-pyrimido<5.4-b><1.4>benzothiazin-5-ium-4-olat

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-10H-pyrimido<5,4-b><1,4>benzothiazine

benzyl bromide

1,3-dimethylbarbituric acid