methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

Base Information

Chemical Name:methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate
CAS No.:203718-33-6
Molecular Formula:C₁₇H₂₄N₂O₇
Molecular Weight:368.387
Hs Code.:

Synonyms:methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

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Chemical Property of methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

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Technology Process of methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

There total 7 articles about methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 203718-30-3
methyl 2-acetamido-3-[2-(acetoxymethyl)-5-cyclohexyl-3-oxoisoxazolin-4-yl]-2-(methoxycarbonyl)propanoate

: 203718-33-6
methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

Guidance literature:: With sodium methylate; In methanol; for 6h; Heating;
DOI:10.1016/S0968-0896(97)10017-7

Reference yield:

: 27772-75-4
5-cyclohexyl-3-hydroxyisoxazole

: 203718-33-6
methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. HBr / 20 h / 60 °C

2.1: 2.14 g / CH₂Cl₂ / 2 h / 20 °C

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: 99 percent / dimethylformamide / 20 h / 20 °C

4.1: 70 percent / BF₃*Et₂O / CHCl₃ / 20 °C

5.1: 79 percent / MeONa / methanol / 6 h / Heating

With boron trifluoride diethyl etherate; hydrogen bromide; sodium methylate; sodium hydride; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Alkylation / 2.1: Etherification / 3.1: Metallation / 3.2: Sorensen reaction / 4.1: Acetylation / 5.1: deprotection;
DOI:10.1016/S0968-0896(97)10017-7

Reference yield:

: 81852-61-1
2,3-dibromo-3-cyclohexylpropionic acid methyl ester

: 203718-33-6
methyl 2-acetamido-3-(5-cyclohexyl-3-hydroxyisoxazol-4-yl)-2-(methoxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 61 percent / N-hydroxyurea; NaOH / methanol / 26 h / 20 °C / Heating

2.1: aq. HBr / 20 h / 60 °C

3.1: 2.14 g / CH₂Cl₂ / 2 h / 20 °C

4.1: NaH / dimethylformamide / 1 h / 0 °C

4.2: 99 percent / dimethylformamide / 20 h / 20 °C

5.1: 70 percent / BF₃*Et₂O / CHCl₃ / 20 °C

6.1: 79 percent / MeONa / methanol / 6 h / Heating

With sodium hydroxide; N-hydroxyurea; boron trifluoride diethyl etherate; hydrogen bromide; sodium methylate; sodium hydride; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Cyclization / 2.1: Alkylation / 3.1: Etherification / 4.1: Metallation / 4.2: Sorensen reaction / 5.1: Acetylation / 6.1: deprotection;
DOI:10.1016/S0968-0896(97)10017-7