4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

Base Information

Chemical Name:4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one
CAS No.:1447913-74-7
Molecular Formula:C₂₂H₁₉ClN₄O₂
Molecular Weight:406.871
Hs Code.:

Synonyms:4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

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Chemical Property of 4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

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Technology Process of 4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

There total 5 articles about 4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1447913-75-8
6-bromo-2-cyclopropyl-3-methylimidazo[1,2-b]pyridazine

: 191090-84-3
4-{[(4-chlorophenyl)methyl]oxy}-2(1H)-pyridinone

: 1447913-74-7
4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 150 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmc.2016.04.011

Reference yield:

: 34650-66-3
2-bromo-1-cyclopropylpropan-1-one

: 1447913-74-7
4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl acetamide / 20 - 80 °C

2: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation

With copper(l) iodide; sodium hydrogencarbonate; potassium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 35421-08-0
4-hydroxybenzyl chloride

: 1447913-74-7
4-((4-chlorobenzyl)oxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 5 h / 20 °C

2.1: acetic anhydride / methanol / 2 h / 140 °C

3.1: N,N`-dimethylethylenediamine; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation

With copper(l) iodide; acetic anhydride; sodium hydride; potassium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2016.04.011