2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

Base Information

Chemical Name:2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid
CAS No.:1297599-47-3
Molecular Formula:C₁₆H₁₂BrCl₂FN₂O₃
Molecular Weight:450.091
Hs Code.:

Synonyms:2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

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Chemical Property of 2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

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Technology Process of 2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

There total 7 articles about 2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 880348-30-1
3-bromo-4-fluoro-L-phenylalanine hydrochloride

: 77423-12-2
6,7-dichloro-1,2-dihydro-3,1-benzoxazine-2,4-dione

: 1297599-47-3
2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

Guidance literature:: With sodium carbonate; In water; at 20 ℃; for 16h; pH=8; chemoselective reaction;
DOI:10.1039/c0ob01004a

Reference yield:

: 880386-25-4
3-bromo-4-fluoro-L-phenylalanine

: 1297599-47-3
2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water / 0 °C

2: hydrogenchloride; water / 3 h / 100 °C

3: sodium carbonate / water / 16 h / 20 °C / pH 8

With hydrogenchloride; water; sodium hydrogencarbonate; sodium carbonate; In water;
DOI:10.1039/c0ob01004a

Reference yield:

: 4-(3-bromo-4-fluorobenzylidene)-2-methyloxazol-5(4H)-one

: 1297599-47-3
2-(2-amino-4,5-dichlorobenzoylamino)-3-(3-bromo-4-fluorophenyl)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: water; acetic acid / 1 h / 100 °C

2: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen / methanol / 24 h / 20 °C / 1551.49 Torr / Inert atmosphere

3: hydrogenchloride; water / 3 h / 100 °C

4: sodium carbonate / water / 16 h / 20 °C / pH 8

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; water; hydrogen; sodium carbonate; acetic acid; In methanol; water;
DOI:10.1039/c0ob01004a