Amoxicillin trihydrate

Base Information

• Chemical Name: Amoxicillin trihydrate
• CAS No.: 61336-70-7
• Molecular Formula: C₁₆H₁₉N₃O₅S*3H₂O
• Molecular Weight: 419.456
• Hs Code.: 29411000
• European Community (EC) Number: 612-127-4,688-488-7,933-899-1
• Mol file: 61336-70-7.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-,trihydrate, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate,[2S-[2a,5a,6b(S*)]]-;Alfoxil;Amoksina;Amoxyl;Atoksilin;Demoksil;Largopen;Moksilin;Promoxil;Remoxil;Topramoxin;

Chemical Property of Amoxicillin trihydrate

Chemical Property:

• Appearance/Colour: A White CRYSTALLINE powder
• Vapor Pressure: 3.39E-23mmHg at 25°C
• Melting Point: >200oC (dec.)
• Refractive Index: 302 ° (C=0.1, H2O)
• Boiling Point: 743.2 °C at 760 mmHg
• Flash Point: 403.3 °C
• PSA: 185.95000
• Density: 1.54g/cm3
• LogP: 0.85990
• Storage Temp.: 2-8°C
• Solubility.: Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
• Water Solubility.: Soluble in water at 3.4mg/ml.
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 419.13623594
• Heavy Atom Count: 28
• Complexity: 590

Purity/Quality:

99% ^*data from raw suppliers

Amoxicillin trihydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 42/43
• Safety Statements: 36-36/37-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.O.O.O
• Isomeric SMILES: CC1([C@@H](N2[C@H](S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.O.O.O
• Recent EU Clinical Trials: Effect of systemic antibiotic therapy on postoperative complications in patients undergoing wisdom teeth removal surgery. A double-blind, randomised, placebo-controlled Trial
• Uses: Semi-synthetic antibiotic related to Penicillin. Antibacterial. Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.
• Therapeutic Function: Antibacterial

Technology Process of Amoxicillin trihydrate

There total 3 articles about Amoxicillin trihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ N-(4-(2-cyanoacetyl)phenyl)acetamide (252895-07-1) + amoxycillin trihydrate (24356-58-9,61336-70-7)

Guidance literature:

Reference yield:

→ amoxycillin trihydrate (24356-58-9,61336-70-7)

Guidance literature:

Reference yield:

Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate (79473-28-2) → amoxicillin trihydrate (24356-58-9,61336-70-7)

Guidance literature:

With water; at 25 ℃; Rate constant; hydrolysis at pH 7.4;

DOI:10.1248/cpb.29.1986

upstream raw materials:

Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Downstream raw materials:

penicillin G

[Co(amoxicillin)(OH)(H₂O)2]

[Fe(amoxicillin)(OH)2(H₂O)]

[Fe(amoxicillin)(OH)(H₂O)2]

Refernces

• 1、 Murakami,Tamauchi,Yamazaki,Kubo,Kamada,Yata. "Biopharmaceutical study on the oral and rectal administrations of enamine prodrugs of amino acid-like β-lactam antibiotics in rabbits". . p. 1986 - 1997. Retrieved 2007/10/02.