2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

Base Information

Chemical Name:2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole
CAS No.:1596340-58-7
Molecular Formula:C₃₀H₃₂N₂O₃S
Molecular Weight:500.662
Hs Code.:

Synonyms:2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

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Chemical Property of 2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

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Technology Process of 2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

There total 6 articles about 2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51784-73-7
4-(benzothiazol-2-yl)-piperidine

: 1596340-50-9
2-((3-bromopropyloxy)methyl)-2,3-dihydro-3-phenylbenzo[b][1,4]dioxane

: 1596340-58-7
2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

Guidance literature:: With potassium carbonate; In acetone; for 12h; Reflux;
DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

: 24127-63-7
(2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methanol

: 1596340-58-7
2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dimethyl sulfoxide / 10 h / 60 °C

2: potassium carbonate / acetone / 12 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; sodium hydroxide; In water; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

: 103-26-4,1754-62-7
methyl cinnamate

: 1596340-58-7
2-(1-(3-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)propyl)piperidin-4-yl)benzo[d]thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / dichloromethane / 20 °C

2.1: potassium carbonate / acetone / 0.25 h / Reflux; Heating

2.2: 1 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dimethyl sulfoxide / 10 h / 60 °C

5.1: potassium carbonate / acetone / 12 h / Reflux

With lithium aluminium tetrahydride; N-benzyl-N,N,N-triethylammonium chloride; bromine; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmcl.2014.02.031