1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

Base Information

Chemical Name:1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester
CAS No.:184090-25-3
Molecular Formula:C₁₅H₁₅ClN₂O₆S
Molecular Weight:386.813
Hs Code.:

1-(5-chloro-2-nitro-benzenesulfonyl)-1<i>H</i>-pyrrole-2-carboxylic acid <i>sec</i>-butyl ester

Synonyms:1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

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Chemical Property of 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

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Technology Process of 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

There total 2 articles about 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 21792-87-0
5-chloro-2-nitrobenzenesulfonyl chloride

: 685563-22-8
sec-butyl 1H-pyrrole-2-carboxylate

: 184090-25-3
1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

Guidance literature:: sec-butyl 1H-pyrrole-2-carboxylate; With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; for 0.25h;

5-chloro-2-nitrobenzenesulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.1016/j.farmac.2003.11.004

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 184090-25-3
1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / K₂CO₃ / 17 h / 60 °C

2.1: t-BuOK; 18-crown-6 / tetrahydrofuran / 0.25 h

2.2: 71 percent / tetrahydrofuran / 3.5 h / 20 °C

With 18-crown-6 ether; potassium tert-butylate; potassium carbonate; In tetrahydrofuran;
DOI:10.1016/j.farmac.2003.11.004