Technology Process of (2-(pyridin-2-yl)-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone
There total 3 articles about (2-(pyridin-2-yl)-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(2-pyridinyl)-1H-indole;
With
methylmagnesium bromide; zinc(II) chloride;
In
diethyl ether; dichloromethane;
at 25 ℃;
for 1h;
Inert atmosphere;
3,4,5-Trimethoxybenzoyl chloride;
In
diethyl ether; dichloromethane;
at 25 ℃;
for 1h;
Inert atmosphere;
With
tin(IV) chloride;
In
diethyl ether; dichloromethane;
at 25 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jm3013097
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: polyphosphoric acid / 1 h / 120 °C
2.1: methylmagnesium bromide; zinc(II) chloride / dichloromethane; diethyl ether / 1 h / 25 °C / Inert atmosphere
2.2: 1 h / 25 °C / Inert atmosphere
2.3: 12 h / 25 °C / Inert atmosphere
With
methylmagnesium bromide; zinc(II) chloride;
In
diethyl ether; dichloromethane;
DOI:10.1021/jm3013097