pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Base Information

• Chemical Name: pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide
• CAS No.: 1276129-61-3
• Molecular Formula: C₂₅H₁₆Cl₂N₄O₂S
• Molecular Weight: 507.4
• Mol file: 1276129-61-3.mol

Synonyms:pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Chemical Property of pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

There total 3 articles about pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-amino-3-chloro-phenyl)-1-(4-chloro-benzyl)-1H-thieno[3,2-d]pyrimidin-4-one (1276129-50-0) + 2-picolinoyl chloride hydrochloride (39901-94-5) → pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide (1276129-61-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 35 ℃;

Reference yield:

6-Bromo-1-(4-chloro-benzyl)-1H-thieno[3,2-d]pyrimidin-4-one (1276129-46-4) → pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide (1276129-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 100 °C

2: triethylamine / dichloromethane / 0 - 35 °C

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)aniline (721960-43-6) → pyridine-2-carboxylic acid {2-chloro-4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide (1276129-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 100 °C

2: triethylamine / dichloromethane / 0 - 35 °C

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

6-(4-amino-3-chloro-phenyl)-1-(4-chloro-benzyl)-1H-thieno[3,2-d]pyrimidin-4-one

2-picolinoyl chloride hydrochloride

2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)aniline

6-Bromo-1-(4-chloro-benzyl)-1H-thieno[3,2-d]pyrimidin-4-one