Pyridine-2-carbonyl chloride hydrochloride

Base Information

• Chemical Name: Pyridine-2-carbonyl chloride hydrochloride
• CAS No.: 39901-94-5
• Molecular Formula: C6H4 Cl N O . Cl H
• Molecular Weight: 178.018
• Hs Code.: 2933399090
• Mol file: 39901-94-5.mol

Synonyms:2-Pyridinecarbonylchloride, hydrochloride (9CI); 2-Picolinoyl chloride hydrochloride;2-Pyridinoyl chloride hydrochloride; Picolinic acid chloride hydrochloride;Picolinoyl chloride hydrochloride

Chemical Property of Pyridine-2-carbonyl chloride hydrochloride

Chemical Property:

• Appearance/Colour: white powder solid
• Vapor Pressure: 0.268mmHg at 25°C
• Melting Point: 123°C
• Boiling Point: 204.1 °C at 760 mmHg
• Flash Point: 77.3 °C
• PSA: 29.96000
• LogP: 2.26260
• Storage Temp.: 0-10°C

Purity/Quality:

99%, ^*data from raw suppliers

Pyridine-2-carbonyl Chloride Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 34-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyridine-2-carbonyl chloride hydrochloride is used in the synthetic preparation of various pharmaceutical goods. Pyridine-2-carbonyl chloride hydrochloride is also used for the synthesis of active est ers of isonicotinic (I821760) and picolinic acids (P437220). Pyridine-2-carbonyl chloride hydrochloride is used in the synthetic preparation of various pharmaceutical goods. Pyridine-2-carbonyl chloride hydrochloride is also used for the synthesis of active esters of isonicotinic (I821760) and picolinic acids (P437220).

Technology Process of Pyridine-2-carbonyl chloride hydrochloride

There total 6 articles about Pyridine-2-carbonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Picolinic acid (98-98-6) → 2-picolinoyl chloride hydrochloride (39901-94-5)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 40.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00240

Reference yield:

3-(2-nitrophenyl)-3-(picolinamido)propanoic acid (1056640-28-8) → C15H15N3O3 + 2-picolinoyl chloride hydrochloride (39901-94-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / N,N-dimethyl-formamide; dichloromethane / 1.5 h / -15 °C / Darkness

1.2: 3 h / 20 °C / Darkness

2.1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 - 20 °C / Inert atmosphere; Darkness

3.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Darkness

4.1: ethanol / 1.5 h / Reflux; Darkness

5.1: pH 7.4 / UV-irradiation

With 4-methyl-morpholine; oxalyl dichloride; chloroformic acid ethyl ester; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3cc38927h

Reference yield:

N-(3-hydroxy-1-(2-nitrophenyl)propyl)picolinamide → C15H15N3O3 + 2-picolinoyl chloride hydrochloride (39901-94-5)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 - 20 °C / Inert atmosphere; Darkness

2: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Darkness

3: ethanol / 1.5 h / Reflux; Darkness

4: pH 7.4 / UV-irradiation

With oxalyl dichloride; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1039/c3cc38927h

upstream raw materials:

2-Picolinic acid

C₂₁H₂₀ClCuN₅O₃

3-(2-nitrophenyl)-3-(picolinamido)propanoic acid

N-(2-formyl-1-(2-nitrophenyl)ethyl)picolinamide

Downstream raw materials:

pyridine-2-carboxylic acid-(2-dimethylamino-ethylamide)

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