(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

Base Information

Chemical Name:(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
CAS No.:147511-69-1
Molecular Formula:C₂₅H₂₄FNO₄
Molecular Weight:421.468
Hs Code.:3004909090
European Community (EC) Number:643-092-3
NSC Number:760423
Wikipedia:Pitavastatin
NCI Thesaurus Code:C87752
RXCUI:861640
Mol file:147511-69-1.mol

Synonyms:(E,3R,5S)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid;itavastatin;itavastatin calcium;nisvastatin;NK 104;NK-104;P 872441;P-872441;pitavastatin;pitavastatin calcium;pitavastatin lactone

Suppliers and Price of (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

CSNpharm
Pitavastatin
10mg
$ 48.00

Crysdot
Pitavastatin 98+%
50mg
$ 84.00

Biosynth Carbosynth
Pitavastatin
5 mg
$ 75.00

Biosynth Carbosynth
Pitavastatin
25 mg
$ 200.00

Biosynth Carbosynth
Pitavastatin
100 mg
$ 550.00

Biosynth Carbosynth
Pitavastatin
50 mg
$ 350.00

Biosynth Carbosynth
Pitavastatin
10 mg
$ 120.00

AvaChem
Pitavastatin
10g
$ 1390.00

AvaChem
Pitavastatin
1g
$ 339.00

AvaChem
Pitavastatin
100mg
$ 69.00

Total 109 raw suppliers

Chemical Property of (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

Chemical Property:

Vapor Pressure:4.21E-20mmHg at 25°C
Refractive Index:1.679
Boiling Point:691.961 °C at 760 mmHg
PKA:4.24±0.10(Predicted)
Flash Point:372.285 °C
PSA：90.65000
Density:1.352 g/cm³
LogP:4.51810
Storage Temp.:-20°C, Hygroscopic
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:461.1315273
Heavy Atom Count:32
Complexity:631

Purity/Quality:

97% ^*data from raw suppliers

Pitavastatin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)O)O)O)C4=CC=C(C=C4)F.[Ca+2]
Isomeric SMILES:C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F.[Ca+2]
Recent ClinicalTrials:Repurposed Drugs in Research for Cancer Clinical Trials- Pitavastatin
Recent EU Clinical Trials:A PHASE 3 STUDY EVALUATING THE EFFECT OF PITAVASTATIN TO PREVENT CARDIOVASCULAR EVENTS IN HIV-1 INFECTED INDIVIDUALS
Recent NIPH Clinical Trials:Effectiveness of Ezetimibe or Pitavastatin calcium calcium in NASH/NAFLD patients with high cholesterol levels: a randomized controlled study
Description Pitavastatin (Brand Name: LIVALO) is an inhibitor of HMG-CoA reductase which catalyzes the first step of cholesterol synthesis. It appears as odorless and white to pale-yellow powder. It takes effects by reducing the level of certain fatty substances such as cholesterol in the body. Therefore, it is mainly indicated for the treatment of hypercholesterolaemia and for the prevention of cardiovascular diseases. It can not only lower the high cholesterol and triglyceride in certain patients, but also can increase the content of high density lipoprotein (HDL), the “good” cholesterol levels. It should be generally administrated together with a proper diet.
Uses HMGA reductase inhibitor

Technology Process of (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

There total 64 articles about (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 849811-78-5
methyl (3R,5S,6E)-7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoate

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;
DOI:10.1039/c4ob01953a

Reference yield: 95.9%

: 147526-32-7
pitavastatin calcium salt

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 25 - 35 ℃;

Reference yield: 94.0%

: 147489-06-3
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

Guidance literature:: (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester; With trifluoroacetic acid; In acetonitrile; at 30 - 35 ℃;

With caesium carbonate; In acetonitrile; at 35 - 40 ℃;