2,6-Dimethoxybenzylamine

Base Information

• Chemical Name: 2,6-Dimethoxybenzylamine
• CAS No.: 20781-22-0
• Molecular Formula: C9H13 N O2
• Molecular Weight: 167.208
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID80384193
• Wikidata: Q72467715
• ChEMBL ID: CHEMBL3139294
• Mol file: 20781-22-0.mol

Synonyms:2,6-Dimethoxybenzylamine;20781-22-0;(2,6-dimethoxyphenyl)methanamine;Benzenemethanamine, 2,6-dimethoxy-;CHEMBL3114406;2,6dimethoxybenzylamine;2,6-dimethoxybenzyiamine;2,6-dimethoxybenzyl amine;SCHEMBL113737;CHEMBL3139294;DTXSID80384193;BDBM50446748;MFCD00052812;AKOS000169408;CS-W017834;TS-02252;FT-0601996;EN300-268435;A814887

Chemical Property of 2,6-Dimethoxybenzylamine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powde
• Vapor Pressure: 0.0139mmHg at 25°C
• Melting Point: 82-86 ºC
• Boiling Point: 108-110°C 1mm
• PKA: 9.23±0.10(Predicted)
• Flash Point: 118.8°C
• PSA: 44.48000
• Density: 1.062g/cm³
• LogP: 1.86280
• Sensitive.: Moisture Sensitive/Air Sensiti
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dimethoxybenzylamine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)OC)CN

Technology Process of 2,6-Dimethoxybenzylamine

There total 5 articles about 2,6-Dimethoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,6-dimethoxybenzonitrile (16932-49-3) → 2,6-Dimethoxybenzylamine (20781-22-0)

Guidance literature:

With potassium borohydride; In ethanol; water; at 20 - 50 ℃;

DOI:10.1021/ja1032277

Reference yield: 67.0%

C17H26N2O4 → 2,6-Dimethoxybenzylamine (20781-22-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 90 ℃; for 12h;

DOI:10.1039/c5ra00114e

Reference yield:

2,6-dimethoxybenzaldehyde (3392-97-0) → 2,6-Dimethoxybenzylamine (20781-22-0)

Guidance literature:

With ammonia; hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave; Green chemistry;

DOI:10.1039/d1gc03578a

upstream raw materials:

2,6-dimethoxybenzonitrile

2,6-dimethoxybenzaldehyde

Downstream raw materials:

2-(3-{(2R)-2-[(2R)-2-([tert-Butyl(dimethyl)silyl]oxy}-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-propyl}-phenyl)-N-(2,6-dimethoxybenzyl)-acetamide