ETHYL 3-(4-CHLOROPHENYL)-5-HYDROXY-1,2,4-TRIAZINE-6-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-(4-CHLOROPHENYL)-5-HYDROXY-1,2,4-TRIAZINE-6-CARBOXYLATE
• CAS No.: 36286-77-8
• Molecular Formula: C₁₂H₁₀ClN₃O₃
• Molecular Weight: 279.683
• Mol file: 36286-77-8.mol

Synonyms:ethyl 3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylate

Chemical Property of ETHYL 3-(4-CHLOROPHENYL)-5-HYDROXY-1,2,4-TRIAZINE-6-CARBOXYLATE

Chemical Property:

• Melting Point: 247-250°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(4-chlorophenyl)-5-hydroxy-1,2,4-triazine-6-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-(4-CHLOROPHENYL)-5-HYDROXY-1,2,4-TRIAZINE-6-CARBOXYLATE

There total 3 articles about ETHYL 3-(4-CHLOROPHENYL)-5-HYDROXY-1,2,4-TRIAZINE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-chlorobenzohydrazonamide (36286-75-6) + Diethyl ketomalonate (609-09-6) → ethyl 3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylate (36286-77-8)

Guidance literature:

In isopropyl alcohol; at 20 ℃; for 18h;

DOI:10.1135/cccc20030965

Reference yield:

4-Cyanochlorobenzene (623-03-0) → ethyl 3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylate (36286-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl / 0 - 20 °C

1.2: 67 percent / aq. N₂H₄*H₂O / ethanol / 48 h / 0 °C

2.1: 68 percent / propan-2-ol / 18 h / 20 °C

With hydrogenchloride; In isopropyl alcohol;

DOI:10.1135/cccc20030965

Reference yield:

→ ethyl 3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylate (36286-77-8)

Guidance literature:

p-Chlorbenzamidrazon, Oxomalonsaeurediethylester;

DOI:10.1021/jo00797a048

upstream raw materials:

4-chlorobenzohydrazonamide

Diethyl ketomalonate

4-Cyanochlorobenzene

Downstream raw materials:

ethyl 5-chloro-3-(4-chlorophenyl)-1,2,4-triazine-6-carboxylate

3-(4-Chloro-phenyl)-[1,2,4]triazine-6-carboxylic acid ethyl ester

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