3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

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Chemical Name:3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate
CAS No.:1258975-46-0
Molecular Formula:C₂HF₃O₂*C₂₂H₂₄N₆O₃S
Molecular Weight:566.561
Hs Code.:

3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

Synonyms:3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

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Chemical Property of 3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

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Technology Process of 3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

There total 9 articles about 3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1258976-20-3
1,1-dimethylethyl 3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]propanoate

: 76-05-1
trifluoroacetic acid

: 1258975-46-0
3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;

Reference yield:

: 1258976-18-9
5-(5-hydrazino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)-oxy]benzonitrile

: 1258975-46-0
3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4: dichloromethane / 7 h / 20 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 5-(5-bromo-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]-benzonitrile

: 1258975-46-0
3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere

2: acetic acid / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5: dichloromethane / 7 h / 20 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b01512