Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate
CAS No.:157327-43-0
Molecular Formula:C12H19 N O4
Molecular Weight:241.28400
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90693849
Mol file:157327-43-0.mol

Synonyms:157327-43-0;TERT-BUTYL 3-ACETYL-4-OXOPIPERIDINE-1-CARBOXYLATE;SCHEMBL2123557;1,1-dimethylethyl 3-acetyl-4-oxo-1-piperidinecarboxylate;DTXSID90693849;FTGIVLQZVUPSAJ-UHFFFAOYSA-N;3-Acetyl-4-oxo-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;MFCD11111801;AKOS015897884;SB23175;A809835;tert-butyl?3-acetyl-4-oxopiperidine-1-carboxylate;J-524514;tert-butyl 3-acetyl-4-oxo-piperidine-1-carboxylate;TERT-BUTYL3-ACETYL-4-OXOPIPERIDINE-1-CARBOXYLATE;3-Acetyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
0.500g
$ 400.00

Matrix Scientific
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
1g
$ 500.00

Crysdot
tert-Butyl3-acetyl-4-oxopiperidine-1-carboxylate 95+%
1g
$ 550.00

Chemenu
tert-Butyl3-acetyl-4-oxopiperidine-1-carboxylate 95%
1g
$ 519.00

Biosynth Carbosynth
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
2 g
$ 900.00

Biosynth Carbosynth
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
500 mg
$ 500.00

Biosynth Carbosynth
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
250 mg
$ 400.00

Biosynth Carbosynth
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
100 mg
$ 300.00

Biosynth Carbosynth
tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate
1 g
$ 600.00

Alichem
Tert-butyl3-acetyl-4-oxopiperidine-1-carboxylate
1g
$ 637.65

Total 11 raw suppliers

Chemical Property of Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate

Chemical Property:

Boiling Point:355.9±42.0 °C(Predicted)
PKA:9.93±0.20(Predicted)
PSA：63.68000
Density:1.135±0.06 g/cm3(Predicted)
LogP:1.33940
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:241.13140809
Heavy Atom Count:17
Complexity:343

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1CN(CCC1=O)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate

There total 16 articles about Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 108-24-7
acetic anhydride

: 157327-43-0
tert-butyl 5-acetyl-4-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With pyrrolidine; In 1,4-dioxane; for 3h; Reflux; Inert atmosphere;

acetic anhydride; In 1,4-dioxane; water; toluene; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 82.0%

: 123-75-1
pyrrolidine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 157327-43-0
tert-butyl 5-acetyl-4-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: In toluene; at 130 ℃; for 5h; Inert atmosphere; Dean-Stark;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield: 56.0%

: 123-75-1
pyrrolidine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 108-24-7
acetic anhydride

: 157327-43-0
tert-butyl 5-acetyl-4-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: pyrrolidine; N-tert-butyloxycarbonylpiperidin-4-one; In toluene; at 92 ℃; for 3h;

acetic anhydride; In 1,4-dioxane; at 20 ℃;

With water; In 1,4-dioxane; for 1h; Reflux;
DOI:10.1039/d0md00085j