{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Base Information

Chemical Name:{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane
CAS No.:503620-06-2
Molecular Formula:C₁₉H₃₂O₃Si
Molecular Weight:336.547
Hs Code.:

Synonyms:{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

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Chemical Property of {2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Chemical Property:

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Technology Process of {2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

There total 7 articles about {2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: (4S,5S)-5-(2-Benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-ol

: 503620-06-2
{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: With magnesium sulfate; toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja021385j

Reference yield:

: 19790-60-4
3-Benzyloxypropanal

: 503620-06-2
{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂ / 0 - 23 °C

1.2: 90 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

2.1: 91 percent / LAH / tetrahydrofuran / 0 - 23 °C

3.1: 86 percent / PhLi / tetrahydrofuran / -78 - 23 °C

4.1: 95 percent / dimethylsulfoxide / 80 °C

5.1: 98 percent / HCl / methanol; H₂O / 48 h / 70 °C

6.1: DIBAL-H / toluene / 3 h / -78 °C

7.1: p-TsOH; MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; titanium tetrachloride; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; phenyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ja021385j

Reference yield:

: 503620-04-0
(2S,3S)-5-(benzyloxy)-2-methylpentane-1,3-diol

: 503620-06-2
{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / PhLi / tetrahydrofuran / -78 - 23 °C

2: 95 percent / dimethylsulfoxide / 80 °C

3: 98 percent / HCl / methanol; H₂O / 48 h / 70 °C

4: DIBAL-H / toluene / 3 h / -78 °C

5: p-TsOH; MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; phenyllithium; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ja021385j