19790-60-4

Basic information

• Product Name: 3-BENZYLOXY-PROPIONALDEHYDE
• Synonyms: 3-BENZYLOXY-PROPIONALDEHYDE;3-(Phenylmethoxy)propanal;3-Benzyloxypropionaldehyde 96%;3-Benzyloxy-1-propanal;Propanal, 3-(phenylmethoxy)-
• CAS NO: 19790-60-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 19790-60-4.mol
• Article Data: 150

Chemical Properties

• Boiling Point: 262.6±15.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.059 g/mL at 25 °C
• Refractive Index: n20/D1.512
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BENZYLOXY-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZYLOXY-PROPIONALDEHYDE(19790-60-4)
• EPA Substance Registry System: 3-BENZYLOXY-PROPIONALDEHYDE(19790-60-4)

Safety Data

• Statements: 52/53
• Safety Statements: 61
• WGK Germany: 3
• Hazardous Substances Data: 19790-60-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 19790-60-4 differently. You can refer to the following data:
1. 3-BENZYLOXY-PROPIONALDEHYDE was used in the chemoenzymatic synthesis of threo- and erythro-β-hydroxy-L-glutamic acid derivatives.
2. 3-(Phenylmethoxy)propanal was used in the chemoenzymatic synthesis of threo- and erythro-β-hydroxy-L-glutamic acid derivatives.

Upstream product

• 78314-63-3 3-benzyloxypropionaldehyde diethyl acetal 
• 143618-78-4 Oxo-phenyl-acetic acid 3-benzyloxy-propyl ester 
• 107-02-8 acrolein 
• 100-51-6 benzyl alcohol 
• 203738-77-6 3-tert-butyldimethylsilyloxy-1-propyl benzyl ether 
• 100-39-0 benzyl bromide 
• 79-37-8 oxalyl dichloride 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 26420-79-1 1-chloro-3-benzyloxypropane 
• 2134-29-4 3-Hydroxypropanal 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 935-04-6 benzyl vinyl ether 
• 201230-82-2 carbon monoxide 
• 88191-39-3 (Z)-((hex-3-en-1-yloxy)-methyl)benzene 

Downstream Products

• 106914-54-9 (3,3-Bis-tert-butylperoxy-propoxymethyl)-benzene 
• 116376-13-7 (4R^*,3R^*)-1-(benzyloxy)-4-methoxy-5-hexen-3-ol 
• 111322-01-1 (R)-1-benzyloxy-hex-5-en-3-ol 
• 91285-62-0 (S)-1-(benzyloxy)-3-hydroxyhex-5-ene 
• 119046-50-3 (E)-5-Benzyloxy-1-trimethylsilanyl-pent-1-en-3-ol 
• 157220-39-8 (4R,5S)-3-((2R,3S)-5-Benzyloxy-3-hydroxy-2-methyl-pentanoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 141401-30-1 4-(3-Benzyloxy-propylamino)-butyric acid methyl ester 
• 95338-10-6 (R)-1,3-pentanediol 1-benzyl ether 
• 95338-12-8 (S)-1,3-pentanediol 1-benzyl ether 
• 108560-42-5 4-Benzyloxy-2-methylamino-butyronitrile 
• 117661-29-7 5-(benzyloxy)pent-1-en-3-ol 
• 138152-64-4 (Z)-5-Benzyloxy-2-methyl-pent-2-enoic acid ethyl ester 
• 107288-65-3 3-Benzyloxy-1-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-propan-1-ol 
• 94989-86-3 5-benzyloxy-3-hydroxy-2-methyl-1-phenyl-pentan-1-one 

Relevant articles and documents

Chiral polypropionate subunit by a chemoenzymatic approach

Enzymatic desymmetrization of meso-4-methyl-3,5-syn-dioxolan- 1,3,5,7- tetrol was found to be highly enantioselective leading to both acetylated enantiomers with high enantiomeric excess.

Asymmetric synthesis of D- and L-2-deoxy-4-thioriboses

Both D- and L-enantiomers of 2-deoxy-4-thioribose derivatives 12 and 17 were prepared stereospecifically in 12 steps from 1,3-propanediol. The key intermediary 2,3-epoxy alcohols, 8 and 15 were obtained with high enantiomeric excess by the Sharpless asymmetric epoxidation using (+)-L- diethyl tartrate and (-)-D-diethyl tartrate.

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice

Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential drugs limited. Previously, we had identified a novel pyrazole-based agonist scaffold. Systematic modification of this scaffold was performed to produce compounds with improved ADME properties. Compound 13 with favorable agonist potency (cAMPi EC50 = 162 nM), human liver microsome stability (T1/2 = 62 min), and pharmacokinetic profile in rodents was identified. The compound was tested in a mouse model of diet-induced obesity (DIO) and metabolic syndrome for efficacy. Treatment with 13 led to significant weight loss, hypophagia, improved glucose utilization, reduced liver steatosis, and improvement of disease-associated biomarkers. In conclusion, a small-molecule agonist of the apelin receptor has been identified that is suitable for in vivo investigation of the apelinergic system in DIO and perhaps other diseases where this receptor has been implicated to play a role.

CYCLOALKYL-CONTAINING CARBOXYLIC ACIDS AND USES THEREOF

The present application discloses a compound of formula (I) or a salt thereof: (I) and compositions comprising such compound or salt thereof. The use of such compound, salt thereof or composition comprising same for treating anemia or leukopenia, fibrosis, cancer, hypertension and/or a metabolic condition in a subject is also disclosed.