Chitosan

Base Information

• Chemical Name: Chitosan
• CAS No.: 9012-76-4
• Molecular Formula: (C6H11NO4)n
• Molecular Weight: 161.16
• Hs Code.: 39139000
• Mol file: 9012-76-4.mol

Synonyms:Flonac C;Chitosan H;Marinkaito F 05N;Marinkaito F 05S;KW 5;TKS 250N;Sea Cure 123;FCM 117;SK 10 (polysaccharide);HC 1 (polysaccharide);North Chitosan MC 1;OTS 2;Sea Cure 143;SK 200;Sea Cure 340;HI-DENSITY CHITOSAN;Chitopearl BCW 3505;Chiton (molluscan common name)Chitopearl 3510;Chitopearl BCW 3507;Hiset KW 5;WOT Recovery Floc T;Kytex M;Sea Cure 243;Chitosan EL;Hydagen HCMF;Profloc 320;

Chemical Property of Chitosan

Chemical Property:

• Appearance/Colour: white Powder
• Melting Point: 88oC
• Refractive Index: 1.7
• PSA: 95.94000
• Density: 1.75g/cm3
• LogP: -1.52550
• Storage Temp.: room temp
• Solubility.: dilute aqueous acid (pH <6.5).: soluble

Purity/Quality:

99% ^*data from raw suppliers

Chitosan, Medium Molecular Weight ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Biomedical Attributes: Chitosan, derived from chitin, possesses desirable biomedical attributes. It is considered one of the most ideal antibacterial materials due to its inherent antibacterial properties, wide source, and high yield.
• Chemical Composition and Properties: Chitosan is a copolymer of glucosamine and N-acetyl glucosamine, derived from chitin. It is composed of varying amounts of (尾1鈫?4) linked residues of N-acetyl-2 amino-2-deoxy-D-glucose (glucosamine) and 2-amino-2-deoxy-D-glucose (N-acetyl-glucosamine) residues. Chitosan is soluble in aqueous acidic media via primary amine protonation.; Reactive groups in chitosan include the primary amino group (C2) and primary and secondary hydroxyl groups (C6, C3), allowing for various modifications and producing polymers with new properties.
• Sources and Production: Chitosan is mainly derived from crustaceans, especially crab, prawns, and shrimp shells, which are readily available as waste from the food processing industry. Commercial chitosan samples were historically produced from the chemical deacetylation of chitin from crustacean sources, but chitosan from fungi is gaining interest, particularly due to vegan demands.
• Market and Industrial Applications: In 2019, the global chitosan market size was valued at USD 6.8 billion. Chitosan serves as a raw material for a wide range of products used in food, medical, pharmaceutical, health care, agriculture, industry, and environmental pollution protection.
• Solubility and Derivatives: The solubility of chitosan depends on the acetylation degree and molecular weight.; Chitosan oligomers are soluble over a wide pH range, while samples with higher molecular weight are only soluble in acidic aqueous media.; Many chitosan derivatives with enhanced solubility have been synthesized to overcome limitations in neutral physiological conditions.
• Biological Activities and Health Benefits: Chitosan exhibits inhibitory effects on bacteria, fungi, and tumor cells. It can induce apoptosis in tumor cells and enhance immune function by promoting the proliferation of T lymphocytes. Chitosan also has reported effects on lowering blood pressure and cholesterol, inhibiting fat absorption, promoting small intestine peristalsis, and improving immunity.
• Applications and Formulation: Chitosan can chemically react with organic reagents and be prepared into various shapes, such as sponge materials, nanoparticles, and gel particles. It is utilized in conventional methods for various applications due to its versatility and ability to form different formulations.

Technology Process of Chitosan

There total 6 articles about Chitosan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chitin, average molecular weight 70 kDa → chitosan (9012-76-4)

Guidance literature:

With sodium hydroxide; In water; for 120h; Reflux;

DOI:10.1002/hlca.200890064

Reference yield: 92.6%

chitin (1398-61-4) → chitosan (9012-76-4)

Guidance literature:

With sodium hydroxide; at 60 ℃; for 72h;

DOI:10.1039/c5ra27489c

Reference yield:

chitosan acetate → chitosan (9012-76-4)

Guidance literature:

With sodium hydroxide; water; for 5h;

upstream raw materials:

chitin

Downstream raw materials:

levulinic acid

N-Acetyl-D-glucosamine

5-hydroxymethyl-2-furfuraldehyde

(1R,1'R,2S,2'S,3R,3'R)-1,1'-(2,5-pyrazine)-bis-1,2,3,4-butanetetraol

Refernces

• 1、 Zu?iga, Adriana,Debbaudt, Adriana,Albertengo, Liliana,Rodríguez, María Susana. "Synthesis and characterization of N-propyl-N-methylene phosphonic chitosan derivative". . p. 475 - 480. Retrieved 2010.
• 2、 Nguyen, Quang D.,Rezessy-Szabó, Judit M.,Czukor, Bálint,Hoschke, ágoston. "Continuous production of oligofructose syrup from Jerusalem artichoke juice by immobilized endo-inulinase". . p. 298 - 303. Retrieved 2011.
• 3、 Soon, Chu Yong,Tee, Yee Bond,Tan, Choon Hui,Rosnita, Abdul Talib,Khalina, Abdan. "Extraction and physicochemical characterization of chitin and chitosan from Zophobas morio larvae in varying sodium hydroxide concentration". . p. 135 - 142. Retrieved 2018.
• 4、 Magesan,Sanuja,Umapathy. "Novel hybrid chitosan blended MoO3-TiO2 nanocomposite film: Evaluation of its solar light photocatalytic and antibacterial activities". . p. 42506 - 42515. Retrieved 2015.
• 5、 Chebotok,Novikov,Konovalova. "Kinetics of base deacetylation of chitin and chitosan as influenced by their crystallinity". . p. 1753 - 1758. Retrieved 2007.
• 6、 Tsai, Min-Lang,Chang, Hsiang-Wei,Yu, Hui-Chuan,Lin, Ya-Shen,Tsai, Ying-Die. "Effect of chitosan characteristics and solution conditions on gelation temperatures of chitosan/2-glycerophosphate/nanosilver hydrogels". . p. 1337 - 1343. Retrieved 2011.