SP 303

Base Information

• Chemical Name: SP 303
• CAS No.: 148465-45-6
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.33124
• Mol file: 148465-45-6.mol

Synonyms:Provir; SP303; Virend

Chemical Property of SP 303

Chemical Property:

• PSA: 303.45000
• LogP: 4.97130

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Crofelemer was approved by the US FDA in December 2012 for the treatment of diarrhea in HIV/AIDS patients on antiretroviral therapy. Crofelemer is indicated for a subset of the population (30–40% of HIV/AIDS cases) whose diarrhea is determined to be noninfective in origin. Crofelemer is an oligomeric proanthocyanidin natural product that is isolated fromthe red latex of Croton lechleri and has been historically used by traditional practitioners of medicine in South America to treat diarrhea. Previously known as SP-303, crofelemer has been shown to inhibit chloride secretion across epithelial cell monolayers, which causes concomitantmovement of water and sodium.
• Uses: Antidiarrheal; antiviral.

Technology Process of SP 303

There total 3 articles about SP 303 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-(1-pyrrolidinyl)-propyl)-3-ethylcarbodiimide → Deloxan ASP I/7 (148465-45-6)

Guidance literature:

With Merrifield's resin (chloromethylated styrene/divinylbenzene copolymer),; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 48h;

Reference yield:

→ Deloxan ASP I/7 (148465-45-6)

Guidance literature:

With sodium hydroxide; 3,3'-dithiobis(propionic acid); In water; pH=4 - 7.4;

Reference yield:

chitosan (9012-76-4) + psyllium → Deloxan ASP I/7 (148465-45-6)

Guidance literature:

chitosan; psyllium; With Pentopan Mono BG; at 20 - 25 ℃; for 42h;

for 0.0166667h; Conversion of starting material; microwave;

upstream raw materials:

chitosan

Downstream raw materials:

2-methyl-1H-benzoimidazole-5-carboxylic acid

2-(2-hydroxyethoxy)ethyl 2-hydroxyethyl terephthalate

Bis(2-Hydroxyethyl)terephthalat

diethylene glycol

Refernces

• 1、 -. "N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS". Page/Page column 30. . Retrieved 2010/02/11.