[6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Base Information

• Chemical Name: [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester
• CAS No.: 135696-34-3
• Molecular Formula: C₁₈H₂₁N₅O₆
• Molecular Weight: 403.395

Synonyms:[6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Chemical Property of [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Chemical Property:

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Technology Process of [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

There total 4 articles about [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

[6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-40-1) → [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-34-3)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00115a005

Reference yield:

3-amino-1-phenoxy-2-butanol (78711-22-5) → [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / Et₃N / ethanol / 23 h / Heating

2: 51 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; chromium(VI) oxide; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/jm00115a005

Reference yield:

3-nitro-1-phenoxy-butan-2-ol (135696-69-4) → [6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-34-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn, aq. H₂SO₄ / ethanol / 18 h / Ambient temperature

2: 77 percent / Et₃N / ethanol / 23 h / Heating

3: 51 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; chromium(VI) oxide; sulfuric acid; triethylamine; zinc; In ethanol; dichloromethane;

DOI:10.1021/jm00115a005

upstream raw materials:

[6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

3-amino-1-phenoxy-2-butanol

3-nitro-1-phenoxy-butan-2-ol

2-phenoxyethanal

Downstream raw materials:

(5-Amino-2-methyl-3-phenoxymethyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester

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