[6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Base Information

• Chemical Name: [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester
• CAS No.: 135696-40-1
• Molecular Formula: C₁₈H₂₃N₅O₆
• Molecular Weight: 405.411

Synonyms:[6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Chemical Property of [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

Chemical Property:

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Technology Process of [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

There total 3 articles about [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-amino-1-phenoxy-2-butanol (78711-22-5) + ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) → [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-40-1)

Guidance literature:

With triethylamine; In ethanol; for 23h; Heating;

DOI:10.1021/jm00115a005

Reference yield:

3-nitro-1-phenoxy-butan-2-ol (135696-69-4) → [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn, aq. H₂SO₄ / ethanol / 18 h / Ambient temperature

2: 77 percent / Et₃N / ethanol / 23 h / Heating

With sulfuric acid; triethylamine; zinc; In ethanol;

DOI:10.1021/jm00115a005

Reference yield:

2-phenoxyethanal (2120-70-9) → [6-Amino-4-(2-hydroxy-1-methyl-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester (135696-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KF-Al₂O₃ / phenylmethanol / 1 h / Ambient temperature

2: Zn, aq. H₂SO₄ / ethanol / 18 h / Ambient temperature

3: 77 percent / Et₃N / ethanol / 23 h / Heating

With potassium fluoride on basic alumina; sulfuric acid; triethylamine; zinc; In ethanol; benzyl alcohol;

DOI:10.1021/jm00115a005

upstream raw materials:

3-amino-1-phenoxy-2-butanol

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

3-nitro-1-phenoxy-butan-2-ol

2-phenoxyethanal

Downstream raw materials:

[6-Amino-4-(1-methyl-2-oxo-3-phenoxy-propylamino)-5-nitro-pyridin-2-yl]-carbamic acid ethyl ester

ethyl <(1RS,2RS)-5,6-diamino-4-<(2-hydroxy-1-methyl-3-phenoxypropyl)amino>pyridin-2-yl>carbamate

(5-Amino-2-methyl-3-phenoxymethyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester

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