N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide
CAS No.:1383724-19-3
Molecular Formula:C₁₅H₁₉N₃O₅S₂
Molecular Weight:385.465
Hs Code.:

Synonyms:N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

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Chemical Property of N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

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Technology Process of N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

There total 4 articles about N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1383724-18-2
tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

: 1383724-19-3
N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1383724-16-0
C₁₄H₂₂N₂O₄S

: 1383724-19-3
N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 - 50 °C / Inert atmosphere

2: triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1383724-17-1
C₁₄H₂₄N₂O₃S

: 1383724-19-3
N-{(R)-2-aminopropyl}-N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;