tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate
CAS No.:1383724-18-2
Molecular Formula:C₂₀H₂₇N₃O₇S₂
Molecular Weight:485.582
Hs Code.:

Synonyms:tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

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Chemical Property of tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

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Technology Process of tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

There total 3 articles about tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383724-17-1
C₁₄H₂₄N₂O₃S

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1383724-18-2
tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 100927-10-4
tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate

: 1383724-18-2
tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 - 50 °C / Inert atmosphere

3: triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 22098-20-0,63075-39-8,128572-14-5
(S)-2-hydroxy-2-(thiophen-3-yl)acetic acid

: 1383724-18-2
tert-butyl (R)-1-[N-{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 - 50 °C / Inert atmosphere

3: triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;