4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

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Chemical Name:4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime
CAS No.:1586758-99-7
Molecular Formula:C₂₄H₂₀F₂N₂O₃
Molecular Weight:422.431
Hs Code.:

Synonyms:4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

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Chemical Property of 4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

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Technology Process of 4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

There total 7 articles about 4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1586758-91-9
N-(1-(4-(bromomethyl)phenyl)-2-chloroethyl)-2,6-difluorobenzamide

: 1586758-99-7
4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

Guidance literature:: p-methoxyl benzaldoxime; With sodium hydride; In N,N-dimethyl-formamide; for 0.666667h;

N-(1-(4-(bromomethyl)phenyl)-2-chloroethyl)-2,6-difluorobenzamide; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-99-7
4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: potassium bromide; potassium bromate; hydrogenchloride / dichloromethane; water / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h

6.2: 0 °C

With potassium bromate; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; iodine; sodium hydride; triethylamine; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 1586758-99-7
4-methoxybenzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 7 h / -10 - 20 °C

2.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

3.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

3.2: 5 h / Reflux

4.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

5.1: thionyl chloride / chloroform / 2.83 h / Reflux

6.1: potassium bromide; potassium bromate; hydrogenchloride / dichloromethane; water / 0 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h

7.2: 0 °C

With potassium bromate; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; iodine; sodium hydride; triethylamine; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1.1: |Friedel-Crafts Acylation;
DOI:10.1021/jf500461a